Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency

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Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency. / Elbæk Mistegård, Clara; Jensen, Lisbeth; Christiansen, Mette et al.

In: Scand. J. Immunol., 08.06.2022.

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@article{e424b54297b14e24b42d59a8605ed09a,
title = "Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency",
abstract = "Patients with common variable immunodeficiency (CVID) display low antibody levels and associated symptoms, including an increased risk of infections. The causes of CVID are uncertain and likely heterogeneous. The complement system protects against pathogens and plays essential roles in homeostasis and development. The influence of the complement system in CVID is not established. We investigated CVID patients and healthy individuals for plasma levels of the complement proteins: MASP-1, MASP-2, MASP-3, MAp19, and MAp44. We also tested other patients with symptoms similar to the CVID patients. CVID patients had lower average MASP-2 and MAp44 levels than healthy individuals (p <0.01); the MASP-2 level was 0.73-fold lower, and the MAp44 level was 0.87-fold lower. This was not observed in the other patient cohorts studied. Our findings in this exploratory study provide new insights into CVID and introduce a complement perspective for future investigations into the underlying mechanisms of the disease.",
author = "{Elb{\ae}k Misteg{\aa}rd}, Clara and Lisbeth Jensen and Mette Christiansen and Mette Bjerre and Jensen, {Jens Magnus Bernth} and Steffen Thiel",
year = "2022",
month = jun,
day = "8",
language = "Dansk",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Low levels of the innate immune system proteins MASP-2 and MAp44 in patients with common variable immunodeficiency

AU - Elbæk Mistegård, Clara

AU - Jensen, Lisbeth

AU - Christiansen, Mette

AU - Bjerre, Mette

AU - Jensen, Jens Magnus Bernth

AU - Thiel, Steffen

PY - 2022/6/8

Y1 - 2022/6/8

N2 - Patients with common variable immunodeficiency (CVID) display low antibody levels and associated symptoms, including an increased risk of infections. The causes of CVID are uncertain and likely heterogeneous. The complement system protects against pathogens and plays essential roles in homeostasis and development. The influence of the complement system in CVID is not established. We investigated CVID patients and healthy individuals for plasma levels of the complement proteins: MASP-1, MASP-2, MASP-3, MAp19, and MAp44. We also tested other patients with symptoms similar to the CVID patients. CVID patients had lower average MASP-2 and MAp44 levels than healthy individuals (p <0.01); the MASP-2 level was 0.73-fold lower, and the MAp44 level was 0.87-fold lower. This was not observed in the other patient cohorts studied. Our findings in this exploratory study provide new insights into CVID and introduce a complement perspective for future investigations into the underlying mechanisms of the disease.

AB - Patients with common variable immunodeficiency (CVID) display low antibody levels and associated symptoms, including an increased risk of infections. The causes of CVID are uncertain and likely heterogeneous. The complement system protects against pathogens and plays essential roles in homeostasis and development. The influence of the complement system in CVID is not established. We investigated CVID patients and healthy individuals for plasma levels of the complement proteins: MASP-1, MASP-2, MASP-3, MAp19, and MAp44. We also tested other patients with symptoms similar to the CVID patients. CVID patients had lower average MASP-2 and MAp44 levels than healthy individuals (p <0.01); the MASP-2 level was 0.73-fold lower, and the MAp44 level was 0.87-fold lower. This was not observed in the other patient cohorts studied. Our findings in this exploratory study provide new insights into CVID and introduce a complement perspective for future investigations into the underlying mechanisms of the disease.

M3 - Tidsskriftartikel

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

ER -