Low frequency rTMS inhibits the anti-depressive effect of ECT: A pilot study

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Low frequency rTMS inhibits the anti-depressive effect of ECT : A pilot study. / Buchholtz, Poul Erik; Ashkanian, Mahmoud; Hjerrild, Simon et al.

In: Acta Neuropsychiatrica, Vol. 32, No. 6, 12.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Buchholtz, PE, Ashkanian, M, Hjerrild, S, Hauptmann, LK, Devantier, TA, Jensen, P, Wissing, S, Thorgaard, M, Bjerager, L, Saugberg, JL, Alrø, A, Speed, M, Brund, RBK & Videbech, P 2020, 'Low frequency rTMS inhibits the anti-depressive effect of ECT: A pilot study', Acta Neuropsychiatrica, vol. 32, no. 6. https://doi.org/10.1017/neu.2020.28

APA

Buchholtz, P. E., Ashkanian, M., Hjerrild, S., Hauptmann, L. K., Devantier, T. A., Jensen, P., Wissing, S., Thorgaard, M., Bjerager, L., Saugberg, J. L., Alrø, A., Speed, M., Brund, R. B. K., & Videbech, P. (2020). Low frequency rTMS inhibits the anti-depressive effect of ECT: A pilot study. Acta Neuropsychiatrica, 32(6). https://doi.org/10.1017/neu.2020.28

CBE

Buchholtz PE, Ashkanian M, Hjerrild S, Hauptmann LK, Devantier TA, Jensen P, Wissing S, Thorgaard M, Bjerager L, Saugberg JL, et al. 2020. Low frequency rTMS inhibits the anti-depressive effect of ECT: A pilot study. Acta Neuropsychiatrica. 32(6). https://doi.org/10.1017/neu.2020.28

MLA

Vancouver

Author

Buchholtz, Poul Erik ; Ashkanian, Mahmoud ; Hjerrild, Simon et al. / Low frequency rTMS inhibits the anti-depressive effect of ECT : A pilot study. In: Acta Neuropsychiatrica. 2020 ; Vol. 32, No. 6.

Bibtex

@article{e5dde582a19e48df8ffb515df14e63a1,
title = "Low frequency rTMS inhibits the anti-depressive effect of ECT: A pilot study",
abstract = "Objective:Low frequency rTMS of the prefrontal cortex have been shown to have a statistically and clinically significant antidepressant effect. The present pilot study was carried out to investigate if right prefrontal low frequency rTMS as an add-on to ECT accelerates the antidepressant effect and reduces cognitive side effects.Methods:In this randomized, controlled, double blind study thirty-five patients with major depression were allocated to ECT+placebo or ECT+ low frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the Major Depression Inventory. Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short lived and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low frequency rTMS could inhibit the antidepressant effect of ECT.",
keywords = "Electroconvulsive therapy (ECT), Keywords:, Low frequency transcranial magnetic stimulation (rTMS), Randomized trial, depression",
author = "Buchholtz, {Poul Erik} and Mahmoud Ashkanian and Simon Hjerrild and Hauptmann, {Line Kirstine} and Devantier, {Torben Albert} and Paulina Jensen and Sanne Wissing and Mette Thorgaard and L{\ae}rke Bjerager and Saugberg, {Julie Lund} and Anja Alr{\o} and Maria Speed and Brund, {Ren{\'e} B{\o}rge Korsgaard} and Poul Videbech",
year = "2020",
month = dec,
doi = "10.1017/neu.2020.28",
language = "English",
volume = "32",
journal = "Acta Neuropsychiatrica",
issn = "0924-2708",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Low frequency rTMS inhibits the anti-depressive effect of ECT

T2 - A pilot study

AU - Buchholtz, Poul Erik

AU - Ashkanian, Mahmoud

AU - Hjerrild, Simon

AU - Hauptmann, Line Kirstine

AU - Devantier, Torben Albert

AU - Jensen, Paulina

AU - Wissing, Sanne

AU - Thorgaard, Mette

AU - Bjerager, Lærke

AU - Saugberg, Julie Lund

AU - Alrø, Anja

AU - Speed, Maria

AU - Brund, René Børge Korsgaard

AU - Videbech, Poul

PY - 2020/12

Y1 - 2020/12

N2 - Objective:Low frequency rTMS of the prefrontal cortex have been shown to have a statistically and clinically significant antidepressant effect. The present pilot study was carried out to investigate if right prefrontal low frequency rTMS as an add-on to ECT accelerates the antidepressant effect and reduces cognitive side effects.Methods:In this randomized, controlled, double blind study thirty-five patients with major depression were allocated to ECT+placebo or ECT+ low frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the Major Depression Inventory. Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short lived and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low frequency rTMS could inhibit the antidepressant effect of ECT.

AB - Objective:Low frequency rTMS of the prefrontal cortex have been shown to have a statistically and clinically significant antidepressant effect. The present pilot study was carried out to investigate if right prefrontal low frequency rTMS as an add-on to ECT accelerates the antidepressant effect and reduces cognitive side effects.Methods:In this randomized, controlled, double blind study thirty-five patients with major depression were allocated to ECT+placebo or ECT+ low frequency right prefrontal rTMS. The severity of depression was evaluated during the course using the Hamilton scale for depression (the 17-item as well as the 6-item scale) and the Major Depression Inventory. Furthermore, neuropsychological assessment of cognitive function was carried out.Results:The study revealed no significant difference between the two groups for any of the outcomes, but with a visible trend to lower scores for MDI after treatment in the placebo group. The negative impact of ECT on neurocognitive functions was short lived and scores on logical memory were significantly improved compared to baseline 4 weeks after last treatment. The ECT-rTMS group revealed generally less impairment of cognitive functions than the ECT-placebo group.Conclusion:The addition of low frequency rTMS as an add-on to ECT treatment did not result in an accelerated response. On the contrary, the results suggest that low frequency rTMS could inhibit the antidepressant effect of ECT.

KW - Electroconvulsive therapy (ECT)

KW - Keywords:

KW - Low frequency transcranial magnetic stimulation (rTMS)

KW - Randomized trial

KW - depression

UR - http://www.scopus.com/inward/record.url?scp=85091844919&partnerID=8YFLogxK

U2 - 10.1017/neu.2020.28

DO - 10.1017/neu.2020.28

M3 - Journal article

C2 - 32713367

VL - 32

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

SN - 0924-2708

IS - 6

ER -