Looking into a Deluded Brain through a Neuroimaging Lens

TY - JOUR

T1 - Looking into a Deluded Brain through a Neuroimaging Lens

AU - Arjmand, Shokouh

AU - Kohlmeier, Kristi A.

AU - Behzadi, Mina

AU - Ilaghi, Mehran

AU - Mazhari, Shahrzad

AU - Shabani, Mohammad

PY - 2021/2

Y1 - 2021/2

N2 - Delusions are irrational, tenacious, and incorrigible false beliefs that are the most common symptom of a range of brain disorders including schizophrenia, Alzheimer’s, and Parkinson’s disease. In the case of schizophrenia and other primary delusional disorders, their appearance is often how the disorder is first detected and can be sufficient for diagnosis. At this time, not much is known about the brain dysfunctions leading to delusions, and hindering our understanding is that the complexity of the nature of delusions, and their very unique relevance to the human experience has hampered elucidation of their underlying neurobiology using either patients or animal models. Advances in neuroimaging along with improved psychiatric and cognitive modeling offers us a new opportunity to look with more investigative power into the deluded brain. In this article, based on data obtained from neuroimaging studies, we have attempted to draw a picture of the neural networks involved when delusion is present and evaluate whether different manifestations of delusions engage different regions of the brain.

AB - Delusions are irrational, tenacious, and incorrigible false beliefs that are the most common symptom of a range of brain disorders including schizophrenia, Alzheimer’s, and Parkinson’s disease. In the case of schizophrenia and other primary delusional disorders, their appearance is often how the disorder is first detected and can be sufficient for diagnosis. At this time, not much is known about the brain dysfunctions leading to delusions, and hindering our understanding is that the complexity of the nature of delusions, and their very unique relevance to the human experience has hampered elucidation of their underlying neurobiology using either patients or animal models. Advances in neuroimaging along with improved psychiatric and cognitive modeling offers us a new opportunity to look with more investigative power into the deluded brain. In this article, based on data obtained from neuroimaging studies, we have attempted to draw a picture of the neural networks involved when delusion is present and evaluate whether different manifestations of delusions engage different regions of the brain.

KW - delusional content

KW - delusional disorders

KW - delusions

KW - fMRI

KW - neuroimaging

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85087786578&partnerID=8YFLogxK

U2 - 10.1177/1073858420936172

DO - 10.1177/1073858420936172

M3 - Review

SN - 1073-8584

VL - 27

SP - 73

EP - 87

JO - The Neuroscientist

JF - The Neuroscientist

IS - 1

ER -