Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Richard B. Banati, Hammersmith Hospital, Charing Cross Hospital
  • ,
  • Annachiara Cagnin, Hammersmith Hospital
  • ,
  • David J. Brooks
  • Roger N. Gunn, Hammersmith Hospital
  • ,
  • Ralph Myers, Hammersmith Hospital
  • ,
  • Terry Jones, Hammersmith Hospital
  • ,
  • Rolfe Birch, Royal National Orthopaedic Hospital NHS Trust
  • ,
  • Praveen Anand, Hammersmith Hospital

Limb denervation leads to reorganization of the representational zones of the somatosensory cortex. Using [11C](R)PK11195, a sensitive in vivo marker of glial cell activation, and PET, we provide first evidence that limb denervation induces a trans-synaptic increase in [11C](R)-PK11195 binding in the human thalamus but not somatosensory cortex: these brain structures appeared morphologically normal on magnetic resonance imaging (MRI). The increased thalamic signal was detectable many years after nerve injury, indicating persistent reorganization of the thalamus. This glial activation, beyond the first-order projection area of the injured neurons, may reflect continually altered afferent activity. Our findings support the view that long-term rearrangement of cortical representational maps is significantly determined within the thalamus.

Original languageEnglish
JournalNeuroReport
Volume12
Issue16
Pages (from-to)3439-3442
Number of pages4
ISSN0959-4965
DOIs
Publication statusPublished - 16 Nov 2001
Externally publishedYes

    Research areas

  • Benzodiazepine, Imaging, Microglia, Pain, Plasticity, Rehabilitation

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