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Long-term reproducibility of GABA magnetic resonance spectroscopy

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  • Jamie Near, Douglas Mental Health University Institute and Department of Psychiatry, McGill University, 6875 LaSalle Blvd, Montreal, H4H 1R3, Canada; Department of Biomedical Engineering, McGill University, Room 316, Duff Medical Building, 3775 Rue University, Montreal, H3A 2B4, Canada. Electronic address: jamie.near@mcgill.ca.
  • ,
  • Yi-Ching Lynn Ho, Center for Functionally Integrative Neuroscience (CFIN), Aarhus University, Nørrebrogade 44, Building 10G, 5th Floor, 8000 Aarhus C, Denmark.
  • ,
  • Kristian Sandberg
  • Chathura Kumaragamage, Department of Biomedical Engineering, McGill University, Room 316, Duff Medical Building, 3775 Rue University, Montreal, H3A 2B4, Canada., Denmark
  • Jakob Blicher

Recent findings suggest that cortical gamma aminobutyric acid (GABA) levels may provide a surrogate marker for a number of psychiatric and neurological conditions, as well as behavioural traits. However, the natural variability of GABA levels in the human brain over long periods of time (>8days) has not yet been studied. The purpose of this work was to investigate the long-term variability of GABA concentrations in the human occipital cortex. Nineteen healthy male participants were recruited and underwent two sessions of magnetic resonance spectroscopy (MRS) to determine occipital GABA levels with an average between-session interval of 7months. We assessed between-session variability, as well as the correlation between session 1 and session 2 GABA measurements. The mean coefficient of variation between sessions was 4.3% (bootstrap 95% confidence interval: 2.5, 6.4), which is comparable to reported GABA variability measurements over much shorter time intervals (<8days). A significant positive correlation was observed between session 1 and session 2 GABA measurements (r=0.53, p=0.014), and the intra-class correlation coefficient was calculated to be 0.52 which was also statistically significant (p=0.012). These findings establish experimentally that GABA concentrations in the occipital cortex as measured by MRS are relatively stable over periods as long as 7months. The findings have significant implications for the internal validity of longitudinal studies of GABA levels in the human brain, and they lend foundational support to studies relating GABA levels to behavioural traits in healthy individuals.

Original languageEnglish
JournalNeuroImage
Pages (from-to)191-196
Number of pages6
ISSN1053-8119
DOIs
Publication statusPublished - 26 May 2014

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