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Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Project

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DOI

  • Jie Chen, Utrecht University
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  • Gerard Hoek, Utrecht University
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  • Kees De Hoogh, Swiss Tropical and Public Health Institute, University of Basel
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  • Sophia Rodopoulou, University of Athens
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  • Zorana J. Andersen, University of Copenhagen
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  • Tom Bellander, Karolinska Institutet, Region Stockholm
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  • Jørgen Brandt
  • Daniela Fecht, Imperial College London
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  • Francesco Forastiere, Department of Epidemiology Lazio Regional Health Service, Imperial College London
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  • John Gulliver, Imperial College London, University of Leicester
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  • Ole Hertel
  • Barbara Hoffmann, Heinrich Heine University Düsseldorf
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  • Ulla Arthur Hvidtfeldt, Danish Cancer Society
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  • W. M.Monique Verschuren, National Institute of Public Health and the Environment, Utrecht University
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  • Karl Heinz Jöckel, University of Duisburg-Essen
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  • Jeanette T. Jørgensen, University of Copenhagen
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  • Klea Katsouyanni, University of Athens, Imperial College London
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  • Matthias Ketzel
  • Diego Yacamán Méndez, Karolinska Institutet, Swedish National Board of Health and Welfare
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  • Karin Leander, Karolinska Institutet
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  • Shuo Liu, University of Copenhagen
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  • Petter Ljungman, Karolinska Institutet
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  • Elodie Faure, Universite Paris-Saclay
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  • Patrik K.E. Magnusson, Karolinska Institutet
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  • Gabriele Nagel, Ulm University
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  • Göran Pershagen, Karolinska Institutet, Region Stockholm
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  • Annette Peters, Helmholtz Zentrum München - German Research Center for Environmental Health, Ludwig Maximilian University of Munich
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  • Ole Raaschou-Nielsen
  • Debora Rizzuto, Stockholm University
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  • Evangelia Samoli, University of Athens
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  • Yvonne T. Van Der Schouw, Utrecht University
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  • Sara Schramm, University of Duisburg-Essen
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  • Gianluca Severi, Universite Paris-Saclay, University of Florence
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  • Massimo Stafoggia, Karolinska Institutet, Department of Epidemiology Lazio Regional Health Service
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  • Maciej Strak, Utrecht University, National Institute of Public Health and the Environment
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  • Mette Sørensen, Danish Cancer Society, Roskilde University
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  • Anne Tjønneland, University of Copenhagen, Danish Cancer Society
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  • Gudrun Weinmayr, Ulm University
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  • Kathrin Wolf, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Emanuel Zitt, LKH Feldkirch, Agency for Preventive and Social Medicine, Bregenz, Austria.
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  • Bert Brunekreef, Utrecht University
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  • George D. Thurston, New York University

We assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3increase) across five identified sources. On a 1 μg/m3basis, the residual oil-related PM2.5had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5mass, suggesting that past estimates using the generic PM2.5exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.

Original languageEnglish
JournalEnvironmental Science and Technology
Volume56
Issue13
Pages (from-to)9277-9290
Number of pages14
ISSN0013-936X
DOIs
Publication statusPublished - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.

    Research areas

  • absolute principal component analysis (APCA), fine particulate matter (PM), mortality, source apportionment

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