Long-Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Jeroen Vendrik, Heart Centre Amsterdam UMC Amsterdam the Netherlands.
  • ,
  • Yousif Ahmad, Imperial College London
  • ,
  • Ashkan Eftekhari
  • James P Howard, Imperial College London
  • ,
  • Gilbert W M Wijntjens, Heart Centre Amsterdam UMC Amsterdam the Netherlands.
  • ,
  • Valerie E Stegehuis, Heart Centre Amsterdam UMC Amsterdam the Netherlands.
  • ,
  • Christopher Cook, Imperial College London
  • ,
  • Christian J Terkelsen
  • ,
  • Evald H Christiansen
  • Karel T Koch, Heart Centre Amsterdam UMC Amsterdam the Netherlands.
  • ,
  • Jan J Piek, Heart Centre Amsterdam UMC Amsterdam the Netherlands.
  • ,
  • Sayan Sen, Imperial College London
  • ,
  • Jan Baan, Heart Centre Amsterdam UMC Amsterdam the Netherlands.

Background As younger patients are being considered for transcatheter aortic valve implantation (TAVI), the assessment and treatment of concomitant coronary artery disease is taking on increased importance. Methods and Results Thirteen contemporary lower-risk patients with TAVI with severe aortic stenosis (AS) and moderate-severe coronary lesions were included. Patients underwent assessment of coronary hemodynamics in the presence of severe AS (pre-TAVI), in the absence of severe AS (immediately post-TAVI), and at longer-term follow-up (6 months post-TAVI). Fractional flow reserve decreased from 0.85 (0.76-0.88) pre-TAVI to 0.79 (0.74-0.83) post-TAVI, and then to 0.71 (0.65-0.77) at 6-month follow-up (P<0.001 for all comparisons). Conversely, instantaneous wave-free ratio was not significantly different: 0.82 (0.80-0.90) pre-TAVI, 0.83 (0.77-0.88) post-TAVI, and 0.83 (0.73-0.89) at 6 months (P=0.735). These changes are explained by the underlying coronary flow. Hyperemic whole-cycle coronary flow (fractional flow reserve flow) increased from 26.36 cm/s (23.82-31.82 cm/s) pre-TAVI to 30.78 cm/s (29.70-34.68 cm/s) post-TAVI (P=0.012), to 40.20 cm/s (32.14-50.00 cm/s) at 6-month follow-up (P<0.001 for both comparisons). Resting flow during the wave-free period of diastole was not significantly different: 25.48 cm/s (21.12-33.65 cm/s) pre-TAVI, 24.54 cm/s (20.74-27.88 cm/s) post-TAVI, and 25.89 cm/s (22.57-28.96 cm/s) at 6 months (P=0.500). Conclusions TAVI acutely improves whole-cycle hyperemic coronary flow, with ongoing sustained improvements at longer-term follow-up. This enhanced response to hyperemic stimuli appears to make fractional flow reserve assessment less suitable for patients with severe AS. Conversely, resting diastolic flow is not significantly influenced by the presence of severe AS. Resting indices of coronary stenosis severity, therefore, appear to be more appropriate for this patient population, although large-scale prospective randomized trials will be required to determine the role of coronary physiology in patients with severe AS.

Original languageEnglish
Article numbere015133
JournalJournal of the American Heart Association
Volume9
Issue5
Number of pages12
ISSN2047-9980
DOIs
Publication statusPublished - Mar 2020

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