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Longitudinal association between mental disorders in childhood and subsequent depression - A nationwide prospective cohort study

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Longitudinal association between mental disorders in childhood and subsequent depression - A nationwide prospective cohort study. / Gundel, Louise Krarup; Pedersen, Carsten Bøcker; Munk-Olsen, Trine; Dalsgaard, Søren.

In: Journal of Affective Disorders, Vol. 227, 2018, p. 56-64.

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@article{5d2274302880417c9106cad7065a7f33,
title = "Longitudinal association between mental disorders in childhood and subsequent depression - A nationwide prospective cohort study",
abstract = "BACKGROUND: Depression ranges among the most impairing mental disorders worldwide, and early detection is a global health priority. Little is known about the association between non-affective mental disorders in childhood/adolescence and later depression.METHODS: Nationwide register-based prospective cohort study, estimating cumulative incidences and incidence rate ratios (IRR) for later depression in individuals with and without non-affective mental disorders in early life.RESULTS: 475,213 females and 484,813 males born 1990-2007 were followed for a mean of 9.14 years (contributing a total of 8778,331 person-years of observation). In the cohort, 7963 (5451 females) were diagnosed with depression. Depression was more common in individuals with prior non-affective mental disorders in adolescence (15.98% in females and 7.02% in males) and in childhood (4.98% in females and 1.6% in males), than in the background population (3.94% and 1.3% in females; 1.37% and 0.47% in males). Eating and anxiety disorders in childhood/adolescence carried the highest absolute risk of depression. The relative risk of depression was particularly high the first year after the first non-affective disorder (IRR = 15.5; 14.07-17.10), but remained highly elevated more than five years after the first non-affective diagnosis (IRR = 2.05; 1.84-2.28), when compared to young people without such disorders.LIMITATIONS: This study only included diagnoses given at hospital departments, representing the more severe mental disorders.CONCLUSIONS: Children and adolescents with non-affective mental disorders were at substantially increased absolute and relative risk of developing depression in young adulthood, especially females diagnosed with anxiety- or eating disorders in adolescence. These findings may help identify groups of children and adolescents at very high risk of developing depression.",
keywords = "Adolescent, Adult, Anxiety/epidemiology, Child, Depression/epidemiology, Feeding and Eating Disorders/epidemiology, Female, Humans, Incidence, Longitudinal Studies, Male, Mental Disorders/epidemiology, Prospective Studies, Registries, Risk, Young Adult",
author = "Gundel, {Louise Krarup} and Pedersen, {Carsten B{\o}cker} and Trine Munk-Olsen and S{\o}ren Dalsgaard",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2018",
doi = "10.1016/j.jad.2017.10.023",
language = "English",
volume = "227",
pages = "56--64",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Longitudinal association between mental disorders in childhood and subsequent depression - A nationwide prospective cohort study

AU - Gundel, Louise Krarup

AU - Pedersen, Carsten Bøcker

AU - Munk-Olsen, Trine

AU - Dalsgaard, Søren

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Depression ranges among the most impairing mental disorders worldwide, and early detection is a global health priority. Little is known about the association between non-affective mental disorders in childhood/adolescence and later depression.METHODS: Nationwide register-based prospective cohort study, estimating cumulative incidences and incidence rate ratios (IRR) for later depression in individuals with and without non-affective mental disorders in early life.RESULTS: 475,213 females and 484,813 males born 1990-2007 were followed for a mean of 9.14 years (contributing a total of 8778,331 person-years of observation). In the cohort, 7963 (5451 females) were diagnosed with depression. Depression was more common in individuals with prior non-affective mental disorders in adolescence (15.98% in females and 7.02% in males) and in childhood (4.98% in females and 1.6% in males), than in the background population (3.94% and 1.3% in females; 1.37% and 0.47% in males). Eating and anxiety disorders in childhood/adolescence carried the highest absolute risk of depression. The relative risk of depression was particularly high the first year after the first non-affective disorder (IRR = 15.5; 14.07-17.10), but remained highly elevated more than five years after the first non-affective diagnosis (IRR = 2.05; 1.84-2.28), when compared to young people without such disorders.LIMITATIONS: This study only included diagnoses given at hospital departments, representing the more severe mental disorders.CONCLUSIONS: Children and adolescents with non-affective mental disorders were at substantially increased absolute and relative risk of developing depression in young adulthood, especially females diagnosed with anxiety- or eating disorders in adolescence. These findings may help identify groups of children and adolescents at very high risk of developing depression.

AB - BACKGROUND: Depression ranges among the most impairing mental disorders worldwide, and early detection is a global health priority. Little is known about the association between non-affective mental disorders in childhood/adolescence and later depression.METHODS: Nationwide register-based prospective cohort study, estimating cumulative incidences and incidence rate ratios (IRR) for later depression in individuals with and without non-affective mental disorders in early life.RESULTS: 475,213 females and 484,813 males born 1990-2007 were followed for a mean of 9.14 years (contributing a total of 8778,331 person-years of observation). In the cohort, 7963 (5451 females) were diagnosed with depression. Depression was more common in individuals with prior non-affective mental disorders in adolescence (15.98% in females and 7.02% in males) and in childhood (4.98% in females and 1.6% in males), than in the background population (3.94% and 1.3% in females; 1.37% and 0.47% in males). Eating and anxiety disorders in childhood/adolescence carried the highest absolute risk of depression. The relative risk of depression was particularly high the first year after the first non-affective disorder (IRR = 15.5; 14.07-17.10), but remained highly elevated more than five years after the first non-affective diagnosis (IRR = 2.05; 1.84-2.28), when compared to young people without such disorders.LIMITATIONS: This study only included diagnoses given at hospital departments, representing the more severe mental disorders.CONCLUSIONS: Children and adolescents with non-affective mental disorders were at substantially increased absolute and relative risk of developing depression in young adulthood, especially females diagnosed with anxiety- or eating disorders in adolescence. These findings may help identify groups of children and adolescents at very high risk of developing depression.

KW - Adolescent

KW - Adult

KW - Anxiety/epidemiology

KW - Child

KW - Depression/epidemiology

KW - Feeding and Eating Disorders/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Longitudinal Studies

KW - Male

KW - Mental Disorders/epidemiology

KW - Prospective Studies

KW - Registries

KW - Risk

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85031745896&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2017.10.023

DO - 10.1016/j.jad.2017.10.023

M3 - Journal article

C2 - 29053976

VL - 227

SP - 56

EP - 64

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -