Long-term daily high-protein, drained yoghurt consumption alters abundance of selected functional groups of the human gut microbiota and fecal short-chain fatty acid profiles in a cohort of overweight and obese women

TY - JOUR

T1 - Long-term daily high-protein, drained yoghurt consumption alters abundance of selected functional groups of the human gut microbiota and fecal short-chain fatty acid profiles in a cohort of overweight and obese women

AU - Yazdi, Fariba Ghiamati

AU - Dalgaard, Line Barner

AU - Li, Qing

AU - Ruscheweyh, Hans-Joachim

AU - Thøgersen, Rebekka

AU - Bertram, Hanne Christine S.

AU - Hansen, Mette

AU - Schwab, Clarissa

PY - 2022/6

Y1 - 2022/6

N2 - The consumption of fermented foods has gained considerable attention due to the ability to deliver live microbes with specific enzymatic activities, and fermentation metabolites, which might play a role in health promotion or disease prevention. The aim of this study was to determine the impact of long-term daily consumption of a high-protein drained yoghurt (Skyr) on intestinal microbial ecology and fermentation activity in a free-living cohort of overweight and obese women (n = 29). Longitudinal analysis and quantitative microbiota profiling identified time intervals with significantly differentially abundant taxa during intervention that differed in functional activity. Our results suggest that ingestion of Skyr persistently modified intestinal microbial cross-feeding activities which altered fecal short chain fatty acid profiles. This study provides a framework indicating the potential of fermented dairy containing starter cultures, lactose and lactate in individualized nutrition or microbiome engineering due to nutritive and microbial components.

AB - The consumption of fermented foods has gained considerable attention due to the ability to deliver live microbes with specific enzymatic activities, and fermentation metabolites, which might play a role in health promotion or disease prevention. The aim of this study was to determine the impact of long-term daily consumption of a high-protein drained yoghurt (Skyr) on intestinal microbial ecology and fermentation activity in a free-living cohort of overweight and obese women (n = 29). Longitudinal analysis and quantitative microbiota profiling identified time intervals with significantly differentially abundant taxa during intervention that differed in functional activity. Our results suggest that ingestion of Skyr persistently modified intestinal microbial cross-feeding activities which altered fecal short chain fatty acid profiles. This study provides a framework indicating the potential of fermented dairy containing starter cultures, lactose and lactate in individualized nutrition or microbiome engineering due to nutritive and microbial components.

KW - Cross-feeding

KW - Fermented dairy

KW - Gut microbiota

KW - Lactate

KW - Lactose

KW - Overweight

U2 - 10.1016/j.jff.2022.105089

DO - 10.1016/j.jff.2022.105089

M3 - Journal article

SN - 1756-4646

VL - 93

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105089

ER -