Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases

Bente Glintborg; Dorte Vendelbo Jensen; Lene Terslev; Oliver Hendricks; Mikkel Østergaard; Simon Horskjær Rasmussen; Mogens Pfeiffer Jensen; Thomas Adelsten; Ada Colic; Kamilla Danebod; Malene Kildemand; Anne Gitte Loft; Heidi Lausten Munk; Jens Kristian Pedersen; René Drage Østgård; Christian Møller Sørensen; Niels Steen Krogh; Jette Nørgaard Agerbo; Connie Ziegler; Merete Lund Hetland

doi:10.3899/jrheum.211280

Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases

Bente Glintborg^*, Dorte Vendelbo Jensen, Lene Terslev, Oliver Hendricks, Mikkel Østergaard, Simon Horskjær Rasmussen, Mogens Pfeiffer Jensen, Thomas Adelsten, Ada Colic, Kamilla Danebod, Malene Kildemand, Anne Gitte Loft, Heidi Lausten Munk, Jens Kristian Pedersen, René Drage Østgård, Christian Møller Sørensen, Niels Steen Krogh, Jette Nørgaard Agerbo, Connie Ziegler, Merete Lund Hetland

^*Corresponding author for this work

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Abstract

Objective. To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination. Methods. A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status. Results. Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation. Conclusion. Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.

Original language	English
Journal	Journal of Rheumatology
Volume	49
Issue	10
Pages (from-to)	1163-1172
Number of pages	10
ISSN	0315-162X
DOIs	https://doi.org/10.3899/jrheum.211280
Publication status	Published - Oct 2022

Keywords

autoimmune diseases
disease outbreaks
registries
rheumatic diseases
vaccines

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Glintborg, B., Jensen, D. V., Terslev, L., Hendricks, O., Østergaard, M., Rasmussen, S. H., Jensen, M. P., Adelsten, T., Colic, A., Danebod, K., Kildemand, M., Loft, A. G., Munk, H. L., Pedersen, J. K., Østgård, R. D., Sørensen, C. M., Krogh, N. S., Agerbo, J. N., Ziegler, C., & Hetland, M. L. (2022). Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases. Journal of Rheumatology, 49(10), 1163-1172. https://doi.org/10.3899/jrheum.211280

@article{19e2f71e1e7a4a80a7ada8ea0eb329d4,

title = "Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases",

abstract = "Objective. To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination. Methods. A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status. Results. Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64\% had rheumatoid arthritis and 63\% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86\%, 50\%, and 52\% of respondents reported self-isolation, respectively. In May 2021, 4\% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86\%, and the proportion of patients vaccinated against influenza had increased from 50\% in winter 2019-2020 to 64\% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation. Conclusion. Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.",

keywords = "autoimmune diseases, disease outbreaks, registries, rheumatic diseases, vaccines",

author = "Bente Glintborg and Jensen, \{Dorte Vendelbo\} and Lene Terslev and Oliver Hendricks and Mikkel {\O}stergaard and Rasmussen, \{Simon Horskj{\ae}r\} and Jensen, \{Mogens Pfeiffer\} and Thomas Adelsten and Ada Colic and Kamilla Danebod and Malene Kildemand and Loft, \{Anne Gitte\} and Munk, \{Heidi Lausten\} and Pedersen, \{Jens Kristian\} and {\O}stg{\aa}rd, \{Ren{\'e} Drage\} and S{\o}rensen, \{Christian M{\o}ller\} and Krogh, \{Niels Steen\} and Agerbo, \{Jette N{\o}rgaard\} and Connie Ziegler and Hetland, \{Merete Lund\}",

year = "2022",

month = oct,

doi = "10.3899/jrheum.211280",

language = "English",

volume = "49",

pages = "1163--1172",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "10",

}

Glintborg, B, Jensen, DV, Terslev, L, Hendricks, O, Østergaard, M, Rasmussen, SH, Jensen, MP, Adelsten, T, Colic, A, Danebod, K, Kildemand, M, Loft, AG, Munk, HL, Pedersen, JK, Østgård, RD, Sørensen, CM, Krogh, NS, Agerbo, JN, Ziegler, C & Hetland, ML 2022, 'Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases', Journal of Rheumatology, vol. 49, no. 10, pp. 1163-1172. https://doi.org/10.3899/jrheum.211280

Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases. / Glintborg, Bente; Jensen, Dorte Vendelbo; Terslev, Lene et al.
In: Journal of Rheumatology, Vol. 49, No. 10, 10.2022, p. 1163-1172.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases

AU - Glintborg, Bente

AU - Jensen, Dorte Vendelbo

AU - Terslev, Lene

AU - Hendricks, Oliver

AU - Østergaard, Mikkel

AU - Rasmussen, Simon Horskjær

AU - Jensen, Mogens Pfeiffer

AU - Adelsten, Thomas

AU - Colic, Ada

AU - Danebod, Kamilla

AU - Kildemand, Malene

AU - Loft, Anne Gitte

AU - Munk, Heidi Lausten

AU - Pedersen, Jens Kristian

AU - Østgård, René Drage

AU - Sørensen, Christian Møller

AU - Krogh, Niels Steen

AU - Agerbo, Jette Nørgaard

AU - Ziegler, Connie

AU - Hetland, Merete Lund

PY - 2022/10

Y1 - 2022/10

N2 - Objective. To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination. Methods. A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status. Results. Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation. Conclusion. Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.

AB - Objective. To explore anxiety and self-isolation in patients with inflammatory rheumatic disease (IRD)15 months into the coronavirus disease 2019 (COVID-19) pandemic, including attitudes toward and effects of SARS-CoV-2 vaccination. Methods. A nationwide online survey was conducted at 3 timepoints: May 2020, November 2020, and May 2021. Patients with IRD followed in the Danish Rheumatology Quality Registry (DANBIO) were asked about the effects of the pandemic, including SARS-CoV-2 infection and their behavior, anxiety, and concerns. The May 2021 survey included attitudes toward SARS-CoV-2 and influenza vaccination. Characteristics associated with self-isolation in May 2021 were explored with adjusted logistic regression analyses that included patient characteristics and SARS-CoV-2 vaccination status. Results. Respondents to surveys 1, 2, and 3 included 12,789; 14,755; and 13,921 patients, respectively; 64% had rheumatoid arthritis and 63% were female. Anxiety and concerns were highest in May 2020 and decreased to stable levels in November 2020 and May 2021; 86%, 50%, and 52% of respondents reported self-isolation, respectively. In May 2021, 4% of respondents self-reported previous SARS-CoV-2 infection. The SARS-CoV-2 vaccine acceptance rate was 86%, and the proportion of patients vaccinated against influenza had increased from 50% in winter 2019-2020 to 64% in winter 2020-2021. The proportion of patients with anxiety appeared similar among those vaccinated and unvaccinated against SARS-CoV-2. In multivariable analyses, being unvaccinated, female gender, receiving biologic drugs, and poor quality of life were independently associated with self-isolation. Conclusion. Levels of anxiety and self-isolation decreased after the initial lockdown period in patients with IRD. Half of the patients reported self-isolation in May 2021, a phase that included widespread reopening of society and large-scale vaccination. The lack of prepandemic data prevented a full understanding of the long-term effects of the pandemic on anxiety and self-isolation in patients with IRD.

KW - autoimmune diseases

KW - disease outbreaks

KW - registries

KW - rheumatic diseases

KW - vaccines

UR - http://www.scopus.com/inward/record.url?scp=85140417672&partnerID=8YFLogxK

U2 - 10.3899/jrheum.211280

DO - 10.3899/jrheum.211280

M3 - Journal article

C2 - 35705237

AN - SCOPUS:85140417672

SN - 0315-162X

VL - 49

SP - 1163

EP - 1172

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 10

ER -

Long-term Behavioral Changes During the COVID-19 Pandemic and Impact of Vaccination in Patients With Inflammatory Rheumatic Diseases

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