Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study

Thomas Cole-Hunter; Jiawei Zhang; Rina So; Evangelia Samoli; Shuo Liu; Jie Chen; Maciej Strak; Kathrin Wolf; Gudrun Weinmayr; Sophia Rodopolou; Elizabeth Remfry; Kees de Hoogh; Tom Bellander; Jørgen Brandt; Hans Concin; Emanuel Zitt; Daniela Fecht; Francesco Forastiere; John Gulliver; Barbara Hoffmann; Ulla A. Hvidtfeldt; Karl Heinz Jöckel; Laust H. Mortensen; Matthias Ketzel; Diego Yacamán Méndez; Karin Leander; Petter Ljungman; Elodie Faure; Pei Chen Lee; Alexis Elbaz; Patrik K.E. Magnusson; Gabriele Nagel; Göran Pershagen; Annette Peters; Debora Rizzuto; Roel C.H. Vermeulen; Sara Schramm; Massimo Stafoggia; Klea Katsouyanni; Bert Brunekreef; Gerard Hoek; Youn Hee Lim; Zorana J. Andersen

doi:10.1016/j.envint.2022.107667

Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study

Thomas Cole-Hunter, Jiawei Zhang, Rina So, Evangelia Samoli, Shuo Liu, Jie Chen, Maciej Strak, Kathrin Wolf, Gudrun Weinmayr, Sophia Rodopolou, Elizabeth Remfry, Kees de Hoogh, Tom Bellander, Jørgen Brandt, Hans Concin, Emanuel Zitt, Daniela Fecht, Francesco Forastiere, John Gulliver, Barbara HoffmannUlla A. Hvidtfeldt, Karl Heinz Jöckel, Laust H. Mortensen, Matthias Ketzel, Diego Yacamán Méndez, Karin Leander, Petter Ljungman, Elodie Faure, Pei Chen Lee, Alexis Elbaz, Patrik K.E. Magnusson, Gabriele Nagel, Göran Pershagen, Annette Peters, Debora Rizzuto, Roel C.H. Vermeulen, Sara Schramm, Massimo Stafoggia, Klea Katsouyanni, Bert Brunekreef, Gerard Hoek, Youn Hee Lim, Zorana J. Andersen^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), black carbon (BC), and ozone (O₃), as well as 8 PM_2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM_2.5 (hazard ratio per 5 µg/m³: 1.25; 95% confidence interval: 1.01–1.55), NO₂ (1.13; 0.95–1.34 per 10 µg/m³), and BC (1.12; 0.94–1.34 per 0.5 × 10^-5m^-1), and a negative association with O₃ (0.74; 0.58–0.94 per 10 µg/m³). Associations of PM_2.5, NO₂, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM_2.5 remained robust when adjusted for NO₂ (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO₂ or BC attenuated to null. O₃ associations remained negative, but no longer statistically significant in models with PM_2.5. We detected suggestive positive associations with the potassium component of PM_2.5. Conclusion: Long-term exposure to PM_2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.

Original language	English
Article number	107667
Journal	Environment International
Volume	171
ISSN	0160-4120
DOIs	https://doi.org/10.1016/j.envint.2022.107667
Publication status	Published - Jan 2023

Keywords

Adults
Air pollution
Long-term exposure
Low-level exposure
Parkinson's Disease
Pooled-cohort study

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Cole-Hunter, T., Zhang, J., So, R., Samoli, E., Liu, S., Chen, J., Strak, M., Wolf, K., Weinmayr, G., Rodopolou, S., Remfry, E., de Hoogh, K., Bellander, T., Brandt, J., Concin, H., Zitt, E., Fecht, D., Forastiere, F., Gulliver, J., ... Andersen, Z. J. (2023). Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study. Environment International, 171, Article 107667. https://doi.org/10.1016/j.envint.2022.107667

@article{737b70cdc8bc40e0922f44c3931284a1,

title = "Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study",

abstract = "Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project {\textquoteleft}Effects of Low-Level Air Pollution: A Study in Europe{\textquoteright} (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5. Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.",

keywords = "Adults, Air pollution, Long-term exposure, Low-level exposure, Parkinson's Disease, Pooled-cohort study",

author = "Thomas Cole-Hunter and Jiawei Zhang and Rina So and Evangelia Samoli and Shuo Liu and Jie Chen and Maciej Strak and Kathrin Wolf and Gudrun Weinmayr and Sophia Rodopolou and Elizabeth Remfry and {de Hoogh}, Kees and Tom Bellander and J{\o}rgen Brandt and Hans Concin and Emanuel Zitt and Daniela Fecht and Francesco Forastiere and John Gulliver and Barbara Hoffmann and Hvidtfeldt, {Ulla A.} and J{\"o}ckel, {Karl Heinz} and Mortensen, {Laust H.} and Matthias Ketzel and {Yacam{\'a}n M{\'e}ndez}, Diego and Karin Leander and Petter Ljungman and Elodie Faure and Lee, {Pei Chen} and Alexis Elbaz and Magnusson, {Patrik K.E.} and Gabriele Nagel and G{\"o}ran Pershagen and Annette Peters and Debora Rizzuto and Vermeulen, {Roel C.H.} and Sara Schramm and Massimo Stafoggia and Klea Katsouyanni and Bert Brunekreef and Gerard Hoek and Lim, {Youn Hee} and Andersen, {Zorana J.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2023",

month = jan,

doi = "10.1016/j.envint.2022.107667",

language = "English",

volume = "171",

journal = "Environment International",

issn = "0160-4120",

publisher = "Pergamon Press",

}

Cole-Hunter, T, Zhang, J, So, R, Samoli, E, Liu, S, Chen, J, Strak, M, Wolf, K, Weinmayr, G, Rodopolou, S, Remfry, E, de Hoogh, K, Bellander, T, Brandt, J, Concin, H, Zitt, E, Fecht, D, Forastiere, F, Gulliver, J, Hoffmann, B, Hvidtfeldt, UA, Jöckel, KH, Mortensen, LH, Ketzel, M, Yacamán Méndez, D, Leander, K, Ljungman, P, Faure, E, Lee, PC, Elbaz, A, Magnusson, PKE, Nagel, G, Pershagen, G, Peters, A, Rizzuto, D, Vermeulen, RCH, Schramm, S, Stafoggia, M, Katsouyanni, K, Brunekreef, B, Hoek, G, Lim, YH & Andersen, ZJ 2023, 'Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study', Environment International, vol. 171, 107667. https://doi.org/10.1016/j.envint.2022.107667

Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study. / Cole-Hunter, Thomas; Zhang, Jiawei; So, Rina et al.
In: Environment International, Vol. 171, 107667, 01.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort

T2 - An ELAPSE study

AU - Cole-Hunter, Thomas

AU - Zhang, Jiawei

AU - So, Rina

AU - Samoli, Evangelia

AU - Liu, Shuo

AU - Chen, Jie

AU - Strak, Maciej

AU - Wolf, Kathrin

AU - Weinmayr, Gudrun

AU - Rodopolou, Sophia

AU - Remfry, Elizabeth

AU - de Hoogh, Kees

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Concin, Hans

AU - Zitt, Emanuel

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla A.

AU - Jöckel, Karl Heinz

AU - Mortensen, Laust H.

AU - Ketzel, Matthias

AU - Yacamán Méndez, Diego

AU - Leander, Karin

AU - Ljungman, Petter

AU - Faure, Elodie

AU - Lee, Pei Chen

AU - Elbaz, Alexis

AU - Magnusson, Patrik K.E.

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Peters, Annette

AU - Rizzuto, Debora

AU - Vermeulen, Roel C.H.

AU - Schramm, Sara

AU - Stafoggia, Massimo

AU - Katsouyanni, Klea

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Lim, Youn Hee

AU - Andersen, Zorana J.

PY - 2023/1

Y1 - 2023/1

N2 - Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5. Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.

AB - Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5. Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.

KW - Adults

KW - Air pollution

KW - Long-term exposure

KW - Low-level exposure

KW - Parkinson's Disease

KW - Pooled-cohort study

UR - http://www.scopus.com/inward/record.url?scp=85143661053&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2022.107667

DO - 10.1016/j.envint.2022.107667

M3 - Journal article

C2 - 36516478

AN - SCOPUS:85143661053

SN - 0160-4120

VL - 171

JO - Environment International

JF - Environment International

M1 - 107667

ER -

Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study

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