Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma

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DOI

  • Rona Chandrawati, Imperial College London, London, UK.
  • ,
  • Jason Y. H. Chang, Imperial College London, London, UK.
  • ,
  • Ester Reina-Torres, Imperial College London, London, UK.
  • ,
  • Coline Jumeaux, Imperial College London, London, UK.
  • ,
  • Joseph M. Sherwood, Imperial College London, London, UK.
  • ,
  • W. Daniel Stamer, Duke University
  • ,
  • Alexander N. Zelikin
  • Darryl R. Overby, Imperial College London, London, UK.
  • ,
  • Molly M. Stevens, Imperial College London, London, UK.

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location-and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.

Original languageEnglish
Article number1604932
JournalAdvanced Materials
Volume29
Issue16
Number of pages8
ISSN0935-9648
DOIs
Publication statusPublished - 25 Apr 2017

    Research areas

  • OPEN-ANGLE GLAUCOMA, HUMAN TRABECULAR MESHWORK, AQUEOUS-HUMOR OUTFLOW, LATANOPROSTENE BUNOD 0.024-PERCENT, TIMOLOL MALEATE 0.5-PERCENT, SOLUBLE GUANYLATE-CYCLASE, INTRAOCULAR-PRESSURE, OCULAR HYPERTENSION, DRUG-DELIVERY, CILIARY MUSCLE

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