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Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Thorbjørn Erik Køppen Christensen
  • Maiken Berglund Davidsen
  • ,
  • Stijn Van Malderen, German Electron Synchrotron
  • ,
  • Jan Garrevoet, German Electron Synchrotron
  • ,
  • Vincent Offermanns, Private Practice Die Kieferchirurgen, 6122 Fritzens, Austria, Austria
  • Ole Zoffmann Andersen, Elos Medtech Pinol A/S
  • ,
  • Morten Foss
  • Henrik Birkedal

It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone-implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.

Original languageEnglish
JournalACS Biomaterials Science and Engineering
Pages (from-to)620-625
Number of pages6
Publication statusPublished - Feb 2022

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