Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

Thorbjørn Erik Køppen Christensen; Maiken Berglund Davidsen; Stijn  Van Malderen; Jan Garrevoet; Vincent Offermanns; Ole Zoffmann Andersen; Morten Foss; Henrik Birkedal

doi:10.1021/acsbiomaterials.1c01004

Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

Thorbjørn Erik Køppen Christensen, Maiken Berglund Davidsen, Stijn Van Malderen, Jan Garrevoet, Vincent Offermanns, Ole Zoffmann Andersen, Morten Foss^*, Henrik Birkedal^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone-implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.

Original language	English
Journal	ACS Biomaterials Science and Engineering
Volume	8
Issue	2
Pages (from-to)	620-625
Number of pages	6
DOIs	https://doi.org/10.1021/acsbiomaterials.1c01004
Publication status	Published - Feb 2022

Access to Document

10.1021/acsbiomaterials.1c01004

6 Citations
1 Ph.D. thesis

Imaging Insights on Club Crystallites and Osteoorientations
Christensen, T. E. K., 31 Jan 2023, (Submitted) 362 p.
Research output: Book/anthology/dissertation/report › Ph.D. thesis

Cite this

Christensen, T. E. K., Davidsen, M. B., Van Malderen, S., Garrevoet, J., Offermanns, V., Andersen, O. Z., Foss, M., & Birkedal, H. (2022). Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone. ACS Biomaterials Science and Engineering, 8(2), 620-625. https://doi.org/10.1021/acsbiomaterials.1c01004

@article{3e930bd50de94dcd9b0187d90e9a8f07,

title = "Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone",

abstract = "It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone-implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.",

keywords = "strontium coating, bone formation, implant, osseointegration, X-ray fluorescence, synchrotron",

author = "Christensen, {Thorbj{\o}rn Erik K{\o}ppen} and Davidsen, {Maiken Berglund} and {Van Malderen}, Stijn and Jan Garrevoet and Vincent Offermanns and Andersen, {Ole Zoffmann} and Morten Foss and Henrik Birkedal",

year = "2022",

month = feb,

doi = "10.1021/acsbiomaterials.1c01004",

language = "English",

volume = "8",

pages = "620--625",

journal = "ACS Biomaterials Science and Engineering",

issn = "2373-9878",

publisher = "American Chemical Society",

number = "2",

}

Christensen, TEK, Davidsen, MB, Van Malderen, S, Garrevoet, J, Offermanns, V, Andersen, OZ, Foss, M & Birkedal, H 2022, 'Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone', ACS Biomaterials Science and Engineering, vol. 8, no. 2, pp. 620-625. https://doi.org/10.1021/acsbiomaterials.1c01004

Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone. / Christensen, Thorbjørn Erik Køppen; Davidsen, Maiken Berglund; Van Malderen, Stijn et al.
In: ACS Biomaterials Science and Engineering, Vol. 8, No. 2, 02.2022, p. 620-625.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

AU - Christensen, Thorbjørn Erik Køppen

AU - Davidsen, Maiken Berglund

AU - Van Malderen, Stijn

AU - Garrevoet, Jan

AU - Offermanns, Vincent

AU - Andersen, Ole Zoffmann

AU - Foss, Morten

AU - Birkedal, Henrik

PY - 2022/2

Y1 - 2022/2

N2 - It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone-implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.

AB - It is well known that strontium (Sr) has a significant effect on peri-implant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone-implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 μm from the implant.

KW - strontium coating, bone formation, implant, osseointegration, X-ray fluorescence, synchrotron

U2 - 10.1021/acsbiomaterials.1c01004

DO - 10.1021/acsbiomaterials.1c01004

M3 - Journal article

C2 - 35099935

SN - 2373-9878

VL - 8

SP - 620

EP - 625

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 2

ER -

Local Release of Strontium from Sputter-Deposited Coatings at Implants Increases the Strontium-to-Calcium Ratio in Peri-implant Bone

Abstract

Access to Document

Fingerprint

Research output

Imaging Insights on Club Crystallites and Osteoorientations

Cite this