Liver protein expression in dairy cows with high liver triglycerides in early lactation

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Liver protein expression in dairy cows with high liver triglycerides in early lactation. / Sejersen, Henrik; Sørensen, Martin Tang; Larsen, Torben; Bendixen, Emøke; Ingvartsen, Klaus Lønne.

In: Journal of Dairy Science, Vol. 95, No. 5, 05.2012, p. 2409-2421.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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@article{f6a1deadf8834646ac0a787e14a704c8,
title = "Liver protein expression in dairy cows with high liver triglycerides in early lactation",
abstract = "Fatty liver is a frequent subclinical health disorder in dairy cows that may lead to disorders related to the liver function. However, the effect of triglyceride(TG) accumulation on liver metabolic pathways is still unclear. The objective was, therefore, to characterize quantitative differences in the liver proteome betweenearly lactation dairy cows with a low or high liver TG content. The liver proteome analysis indicated that a high liver TG content in early lactation dairy cows isassociated with increased oxidation of saturated fatty acids, oxidative stress, and urea synthesis and decreasedoxidation of unsaturated fatty acids. Furthermore,liver gluconeogenesis is apparently not impaired by an increased liver TG content. Based on correlations between liver proteins and plasma components, we suggest that future studies investigate the sensitivity and specificity of plasma aspartate aminotransferase, β-hydroxybutyrate, total bilirubin, total bile acids, and γ-glutamyltransferase for potential use as blood-basedbiomarkers for early detection of fatty liver in dairy cows. Our study is the first to study the proteome of dairy cows with naturally occurring fatty liver in earlylactation.",
keywords = "proteomics, fatty liver, biomarker, dairy cow",
author = "Henrik Sejersen and S{\o}rensen, {Martin Tang} and Torben Larsen and Em{\o}ke Bendixen and Ingvartsen, {Klaus L{\o}nne}",
year = "2012",
month = may,
doi = "10.3168/jds.2011-4604",
language = "English",
volume = "95",
pages = "2409--2421",
journal = "Journal of Dairy Science",
issn = "0022-0302",
publisher = "Elsevier Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Liver protein expression in dairy cows with high liver triglycerides in early lactation

AU - Sejersen, Henrik

AU - Sørensen, Martin Tang

AU - Larsen, Torben

AU - Bendixen, Emøke

AU - Ingvartsen, Klaus Lønne

PY - 2012/5

Y1 - 2012/5

N2 - Fatty liver is a frequent subclinical health disorder in dairy cows that may lead to disorders related to the liver function. However, the effect of triglyceride(TG) accumulation on liver metabolic pathways is still unclear. The objective was, therefore, to characterize quantitative differences in the liver proteome betweenearly lactation dairy cows with a low or high liver TG content. The liver proteome analysis indicated that a high liver TG content in early lactation dairy cows isassociated with increased oxidation of saturated fatty acids, oxidative stress, and urea synthesis and decreasedoxidation of unsaturated fatty acids. Furthermore,liver gluconeogenesis is apparently not impaired by an increased liver TG content. Based on correlations between liver proteins and plasma components, we suggest that future studies investigate the sensitivity and specificity of plasma aspartate aminotransferase, β-hydroxybutyrate, total bilirubin, total bile acids, and γ-glutamyltransferase for potential use as blood-basedbiomarkers for early detection of fatty liver in dairy cows. Our study is the first to study the proteome of dairy cows with naturally occurring fatty liver in earlylactation.

AB - Fatty liver is a frequent subclinical health disorder in dairy cows that may lead to disorders related to the liver function. However, the effect of triglyceride(TG) accumulation on liver metabolic pathways is still unclear. The objective was, therefore, to characterize quantitative differences in the liver proteome betweenearly lactation dairy cows with a low or high liver TG content. The liver proteome analysis indicated that a high liver TG content in early lactation dairy cows isassociated with increased oxidation of saturated fatty acids, oxidative stress, and urea synthesis and decreasedoxidation of unsaturated fatty acids. Furthermore,liver gluconeogenesis is apparently not impaired by an increased liver TG content. Based on correlations between liver proteins and plasma components, we suggest that future studies investigate the sensitivity and specificity of plasma aspartate aminotransferase, β-hydroxybutyrate, total bilirubin, total bile acids, and γ-glutamyltransferase for potential use as blood-basedbiomarkers for early detection of fatty liver in dairy cows. Our study is the first to study the proteome of dairy cows with naturally occurring fatty liver in earlylactation.

KW - proteomics

KW - fatty liver

KW - biomarker

KW - dairy cow

U2 - 10.3168/jds.2011-4604

DO - 10.3168/jds.2011-4604

M3 - Journal article

C2 - 22541469

VL - 95

SP - 2409

EP - 2421

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

IS - 5

ER -