Lithium dosing strategies during pregnancy and the postpartum period

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Lithium dosing strategies during pregnancy and the postpartum period. / Wesseloo, Richard; Wierdsma, André I.; van Kamp, Inge L.; Munk-Olsen, Trine; Hoogendijk, Witte J. G.; Kushner, Steven A.; Bergink, Veerle.

In: British Journal of Psychiatry, Vol. 211, No. 1, 07.2017, p. 31-36.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Wesseloo, R, Wierdsma, AI, van Kamp, IL, Munk-Olsen, T, Hoogendijk, WJG, Kushner, SA & Bergink, V 2017, 'Lithium dosing strategies during pregnancy and the postpartum period', British Journal of Psychiatry, vol. 211, no. 1, pp. 31-36. https://doi.org/10.1192/bjp.bp.116.192799

APA

Wesseloo, R., Wierdsma, A. I., van Kamp, I. L., Munk-Olsen, T., Hoogendijk, W. J. G., Kushner, S. A., & Bergink, V. (2017). Lithium dosing strategies during pregnancy and the postpartum period. British Journal of Psychiatry, 211(1), 31-36. https://doi.org/10.1192/bjp.bp.116.192799

CBE

Wesseloo R, Wierdsma AI, van Kamp IL, Munk-Olsen T, Hoogendijk WJG, Kushner SA, Bergink V. 2017. Lithium dosing strategies during pregnancy and the postpartum period. British Journal of Psychiatry. 211(1):31-36. https://doi.org/10.1192/bjp.bp.116.192799

MLA

Wesseloo, Richard et al. "Lithium dosing strategies during pregnancy and the postpartum period". British Journal of Psychiatry. 2017, 211(1). 31-36. https://doi.org/10.1192/bjp.bp.116.192799

Vancouver

Wesseloo R, Wierdsma AI, van Kamp IL, Munk-Olsen T, Hoogendijk WJG, Kushner SA et al. Lithium dosing strategies during pregnancy and the postpartum period. British Journal of Psychiatry. 2017 Jul;211(1):31-36. https://doi.org/10.1192/bjp.bp.116.192799

Author

Wesseloo, Richard ; Wierdsma, André I. ; van Kamp, Inge L. ; Munk-Olsen, Trine ; Hoogendijk, Witte J. G. ; Kushner, Steven A. ; Bergink, Veerle. / Lithium dosing strategies during pregnancy and the postpartum period. In: British Journal of Psychiatry. 2017 ; Vol. 211, No. 1. pp. 31-36.

Bibtex

@article{c4947609bf964672a87e2c31506a0eb1,

title = "Lithium dosing strategies during pregnancy and the postpartum period",

abstract = "BackgroundLithium is challenging to dose during pregnancy.AimsTo provide guidance for dosing lithium during pregnancy.MethodRetrospective observational cohort study. Data on lithium blood level measurements (n = 1101), the daily lithium dose, dosing alterations/frequency and creatinine blood levels were obtained from 113 pregnancies of women receiving lithium treatment during pregnancy and the postpartum period.ResultsLithium blood levels decreased in the first trimester (-24%, 95% CI -15 to -35), reached a nadir in the second trimester (-36%, 95% CI -27 to -47), increased in the third trimester (-21%, 95% CI -13 to -30) and were still slightly increased postpartum (+9%, 95% CI +2 to +15). Delivery itself was not associated with an acute change in lithium and creatinine blood levels.ConclusionsWe recommend close monitoring of lithium blood levels until 34 weeks of pregnancy, then weekly until delivery and twice weekly for the first 2 weeks postpartum. We suggest creatinine blood levels are measured to monitor renal clearance.",

keywords = "Journal Article",

author = "Richard Wesseloo and Wierdsma, {Andr{\'e} I.} and {van Kamp}, {Inge L.} and Trine Munk-Olsen and Hoogendijk, {Witte J. G.} and Kushner, {Steven A.} and Veerle Bergink",

note = "{\textcopyright} The Royal College of Psychiatrists 2017.",

year = "2017",

month = jul,

doi = "10.1192/bjp.bp.116.192799",

language = "English",

volume = "211",

pages = "31--36",

journal = "British Journal of Psychiatry",

issn = "0007-1250",

publisher = "ROYAL COLL PSYCHIATRISTS",

number = "1",

}

RIS

TY - JOUR

T1 - Lithium dosing strategies during pregnancy and the postpartum period

AU - Wesseloo, Richard

AU - Wierdsma, André I.

AU - van Kamp, Inge L.

AU - Munk-Olsen, Trine

AU - Hoogendijk, Witte J. G.

AU - Kushner, Steven A.

AU - Bergink, Veerle

PY - 2017/7

Y1 - 2017/7

N2 - BackgroundLithium is challenging to dose during pregnancy.AimsTo provide guidance for dosing lithium during pregnancy.MethodRetrospective observational cohort study. Data on lithium blood level measurements (n = 1101), the daily lithium dose, dosing alterations/frequency and creatinine blood levels were obtained from 113 pregnancies of women receiving lithium treatment during pregnancy and the postpartum period.ResultsLithium blood levels decreased in the first trimester (-24%, 95% CI -15 to -35), reached a nadir in the second trimester (-36%, 95% CI -27 to -47), increased in the third trimester (-21%, 95% CI -13 to -30) and were still slightly increased postpartum (+9%, 95% CI +2 to +15). Delivery itself was not associated with an acute change in lithium and creatinine blood levels.ConclusionsWe recommend close monitoring of lithium blood levels until 34 weeks of pregnancy, then weekly until delivery and twice weekly for the first 2 weeks postpartum. We suggest creatinine blood levels are measured to monitor renal clearance.

AB - BackgroundLithium is challenging to dose during pregnancy.AimsTo provide guidance for dosing lithium during pregnancy.MethodRetrospective observational cohort study. Data on lithium blood level measurements (n = 1101), the daily lithium dose, dosing alterations/frequency and creatinine blood levels were obtained from 113 pregnancies of women receiving lithium treatment during pregnancy and the postpartum period.ResultsLithium blood levels decreased in the first trimester (-24%, 95% CI -15 to -35), reached a nadir in the second trimester (-36%, 95% CI -27 to -47), increased in the third trimester (-21%, 95% CI -13 to -30) and were still slightly increased postpartum (+9%, 95% CI +2 to +15). Delivery itself was not associated with an acute change in lithium and creatinine blood levels.ConclusionsWe recommend close monitoring of lithium blood levels until 34 weeks of pregnancy, then weekly until delivery and twice weekly for the first 2 weeks postpartum. We suggest creatinine blood levels are measured to monitor renal clearance.

KW - Journal Article

U2 - 10.1192/bjp.bp.116.192799

DO - 10.1192/bjp.bp.116.192799

M3 - Journal article

C2 - 28673946

VL - 211

SP - 31

EP - 36

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 1

ER -

Department of Economics and Business Economics