Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

Manon A.A. Jansen; Lasse H. Klausen; Kaushik Thanki; Jeppe Lyngsø; Jan Skov Pedersen; Henrik Franzyk; Hanne Mørck Nielsen; Willem van Eden; Mingdong Dong; Femke Broere; Camilla Foged; Xianghui Zeng

doi:10.1016/j.ejpb.2019.06.009

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

Manon A.A. Jansen, Lasse H. Klausen, Kaushik Thanki, Jeppe Lyngsø, Jan Skov Pedersen, Henrik Franzyk, Hanne Mørck Nielsen, Willem van Eden, Mingdong Dong, Femke Broere, Camilla Foged^*, Xianghui Zeng

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

52 Citations (Scopus)

Original language	English
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	142
Pages (from-to)	38-48
Number of pages	11
ISSN	0939-6411
DOIs	https://doi.org/10.1016/j.ejpb.2019.06.009
Publication status	Published - Sept 2019

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10.1016/j.ejpb.2019.06.009

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Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C., & Zeng, X. (2019). Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model. European Journal of Pharmaceutics and Biopharmaceutics, 142, 38-48. https://doi.org/10.1016/j.ejpb.2019.06.009

@article{5a048274285543feb6c2a8b84c7627c5,

title = "Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model",

keywords = "Arthritis, Lipidoid, Macrophages, Nanoparticle, Vesicles, siRNA, Delivery",

author = "Jansen, {Manon A.A.} and Klausen, {Lasse H.} and Kaushik Thanki and Jeppe Lyngs{\o} and {Skov Pedersen}, Jan and Henrik Franzyk and Nielsen, {Hanne M{\o}rck} and {van Eden}, Willem and Mingdong Dong and Femke Broere and Camilla Foged and Xianghui Zeng",

year = "2019",

month = sep,

doi = "10.1016/j.ejpb.2019.06.009",

language = "English",

volume = "142",

pages = "38--48",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "Elsevier BV",

}

Jansen, MAA, Klausen, LH, Thanki, K, Lyngsø, J, Skov Pedersen, J, Franzyk, H, Nielsen, HM, van Eden, W, Dong, M, Broere, F, Foged, C & Zeng, X 2019, 'Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model', European Journal of Pharmaceutics and Biopharmaceutics, vol. 142, pp. 38-48. https://doi.org/10.1016/j.ejpb.2019.06.009

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model. / Jansen, Manon A.A.; Klausen, Lasse H.; Thanki, Kaushik et al.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142, 09.2019, p. 38-48.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

AU - Jansen, Manon A.A.

AU - Klausen, Lasse H.

AU - Thanki, Kaushik

AU - Lyngsø, Jeppe

AU - Skov Pedersen, Jan

AU - Franzyk, Henrik

AU - Nielsen, Hanne Mørck

AU - van Eden, Willem

AU - Dong, Mingdong

AU - Broere, Femke

AU - Foged, Camilla

AU - Zeng, Xianghui

PY - 2019/9

Y1 - 2019/9

KW - Arthritis

KW - Lipidoid

KW - Macrophages

KW - Nanoparticle

KW - Vesicles

KW - siRNA

KW - Delivery

UR - http://www.scopus.com/inward/record.url?scp=85067283394&partnerID=8YFLogxK

U2 - 10.1016/j.ejpb.2019.06.009

DO - 10.1016/j.ejpb.2019.06.009

M3 - Journal article

C2 - 31199978

AN - SCOPUS:85067283394

SN - 0939-6411

VL - 142

SP - 38

EP - 48

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

ER -

Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model

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