Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery

Yanfang Li; Peter Slemming-Adamsen; Jing Wang; Jie Song; Xueqin Wang; Ying Yu; MD Dong; Chunying Chen; Flemming Besenbacher; Menglin Chen

doi:10.1002/term.2169

Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery

Yanfang Li, Peter Slemming-Adamsen, Jing Wang, Jie Song, Xueqin Wang, Ying Yu, MD Dong, Chunying Chen, Flemming Besenbacher, Menglin Chen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

24 Citations (Scopus)

Abstract

Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology. Combining with the extracellular matrix-mimicking fibrillary properties, the nanofibres achieved accelerated release of model drug or cells on demand with NIR triggering. The release of the model drug doxorubicin demonstrated normal anti-cancer efficacy by reducing the viability of human cervical cancer HeLa cells by 97% in 48 h. In parallel, the fibres allowed model cell NIH3T3 fibroblast entrapment, adhesion, proliferation, differentiation and, upon NIR irradiation, cell release with undisturbed cellular function.

Original language	English
Journal	Journal of Tissue Engineering and Regenerative Medicine
Volume	11
Issue	8
Pages (from-to)	2411–2420
Number of pages	10
ISSN	1932-6254
DOIs	https://doi.org/10.1002/term.2169
Publication status	Published - Aug 2017

Keywords

cell delivery
drug release
light responsive
nanofibres
on-demand

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10.1002/term.2169

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title = "Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery",

abstract = "Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology. Combining with the extracellular matrix-mimicking fibrillary properties, the nanofibres achieved accelerated release of model drug or cells on demand with NIR triggering. The release of the model drug doxorubicin demonstrated normal anti-cancer efficacy by reducing the viability of human cervical cancer HeLa cells by 97% in 48 h. In parallel, the fibres allowed model cell NIH3T3 fibroblast entrapment, adhesion, proliferation, differentiation and, upon NIR irradiation, cell release with undisturbed cellular function.",

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author = "Yanfang Li and Peter Slemming-Adamsen and Jing Wang and Jie Song and Xueqin Wang and Ying Yu and MD Dong and Chunying Chen and Flemming Besenbacher and Menglin Chen",

year = "2017",

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doi = "10.1002/term.2169",

language = "English",

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Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery. / Li, Yanfang; Slemming-Adamsen, Peter; Wang, Jing et al.
In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 11, No. 8, 08.2017, p. 2411–2420.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Li, Yanfang

AU - Slemming-Adamsen, Peter

AU - Wang, Jing

AU - Song, Jie

AU - Wang, Xueqin

AU - Yu, Ying

AU - Dong, MD

AU - Chen, Chunying

AU - Besenbacher, Flemming

AU - Chen, Menglin

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AB - Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology. Combining with the extracellular matrix-mimicking fibrillary properties, the nanofibres achieved accelerated release of model drug or cells on demand with NIR triggering. The release of the model drug doxorubicin demonstrated normal anti-cancer efficacy by reducing the viability of human cervical cancer HeLa cells by 97% in 48 h. In parallel, the fibres allowed model cell NIH3T3 fibroblast entrapment, adhesion, proliferation, differentiation and, upon NIR irradiation, cell release with undisturbed cellular function.

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Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery

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Keywords

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