Light responsive hybrid nanofibres for on-demandtherapeutic drug and cell delivery

Yanfang Li, Peter Slemming-Adamsen, Jing Wang, Jie Song, Xueqin Wang, Ying Yu, MD Dong, Chunying Chen, Flemming Besenbacher, Menglin Chen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology. Combining with the extracellular matrix-mimicking fibrillary properties, the nanofibres achieved accelerated release of model drug or cells on demand with NIR triggering. The release of the model drug doxorubicin demonstrated normal anti-cancer efficacy by reducing the viability of human cervical cancer HeLa cells by 97% in 48 h. In parallel, the fibres allowed model cell NIH3T3 fibroblast entrapment, adhesion, proliferation, differentiation and, upon NIR irradiation, cell release with undisturbed cellular function.

Original languageEnglish
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume11
Issue8
Pages (from-to)2411–2420
Number of pages10
ISSN1932-6254
DOIs
Publication statusPublished - Aug 2017

Keywords

  • cell delivery
  • drug release
  • light responsive
  • nanofibres
  • on-demand

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