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Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

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  • Department of Medical Biochemistry
  • Interdisciplinary Nanoscience Center
  • iNano-School
  • Department of Molecular Biology
The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.
Original languageEnglish
JournalNature Structural and Molecular Biology
Pages (from-to)96-8
Number of pages3
Publication statusPublished - 2009

    Research areas

  • Adaptor Proteins, Vesicular Transport, Animals, Apoptosis, Binding Sites, Ligands, Mammals, Models, Molecular, Neurons, Neurotensin, Protein Binding, Protein Conformation

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ID: 15165981