Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • I. Reuter, King's College and King's College Hospital
  • ,
  • M. T.M. Hu, King's College and King's College Hospital, Hammersmith Hospital
  • ,
  • T. C. Andrews, Hammersmith Hospital
  • ,
  • D. J. Brooks
  • C. Clough, King's College and King's College Hospital
  • ,
  • K. Ray Chaudhuri, King's College and King's College Hospital, University Hospital Lewishom

Huntington's disease is characterised by hyperkinetic movements, mainly chorea, cognitive dysfunction, and psychiatric abnormalities. Non-dopa responsive parkinsonism occurs in the later stages of choreic disease or as the predominant feature of juvenile patients (Westphal variant). Late onset Huntington's disease presenting as levodopa responsive parkinsonism is rare. A series of four patients with late onset Huntington's disease presenting as levodopa responsive parkinsonism and cardiovascular dysautonomia, initially misdiagnosed as multiple system atrophy (MSA) in three patients, is reported. Levodopa treatment did not unmask significant chorea. These cases suggest the presence of a distinct phenotypic variant of Huntington's disease to be added to the differential diagnosis of other akinetic rigid syndromes.

Original languageEnglish
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume68
Issue2
Pages (from-to)238-241
Number of pages4
ISSN0022-3050
DOIs
Publication statusPublished - 1 Feb 2000
Externally publishedYes

    Research areas

  • Chorea, Dopa-responsive, Huntington's disease, Multiple system atrophy, Postural hypotension

See relations at Aarhus University Citationformats

ID: 131705365