Department of Economics and Business Economics

Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. / Sølvsten Burgdorf, Kristoffer; Trabjerg, Betina; Giørtz Pedersen, Marianne; Nissen, Janna; Banasik, Karina; Birger Pedersen, Ole; Sørensen, Erik; René Nielsen, Kaspar; Hørup Larsen, Margit; Erikstrup, Christian; Bruun-Rasmussen, Peter; Westergaard, David; Wegner Thørner, Lise; Hjalgrim, Henrik; Martina Paarup, Helene; Brunak, Søren; Pedersen, Carsten B; Fuller Torrey, E; Werge, Thomas; Bo Mortensen, Preben; Yolken, Robert; Ullum, Henrik.

In: Brain, Behavior, and Immunity, Vol. 79, 07.2019, p. 152-158.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sølvsten Burgdorf, K, Trabjerg, B, Giørtz Pedersen, M, Nissen, J, Banasik, K, Birger Pedersen, O, Sørensen, E, René Nielsen, K, Hørup Larsen, M, Erikstrup, C, Bruun-Rasmussen, P, Westergaard, D, Wegner Thørner, L, Hjalgrim, H, Martina Paarup, H, Brunak, S, Pedersen, CB, Fuller Torrey, E, Werge, T, Bo Mortensen, P, Yolken, R & Ullum, H 2019, 'Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders', Brain, Behavior, and Immunity, vol. 79, pp. 152-158. https://doi.org/10.1016/j.bbi.2019.01.026

APA

Sølvsten Burgdorf, K., Trabjerg, B., Giørtz Pedersen, M., Nissen, J., Banasik, K., Birger Pedersen, O., ... Ullum, H. (2019). Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity, 79, 152-158. https://doi.org/10.1016/j.bbi.2019.01.026

CBE

Sølvsten Burgdorf K, Trabjerg B, Giørtz Pedersen M, Nissen J, Banasik K, Birger Pedersen O, Sørensen E, René Nielsen K, Hørup Larsen M, Erikstrup C, Bruun-Rasmussen P, Westergaard D, Wegner Thørner L, Hjalgrim H, Martina Paarup H, Brunak S, Pedersen CB, Fuller Torrey E, Werge T, Bo Mortensen P, Yolken R, Ullum H. 2019. Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity. 79:152-158. https://doi.org/10.1016/j.bbi.2019.01.026

MLA

Vancouver

Sølvsten Burgdorf K, Trabjerg B, Giørtz Pedersen M, Nissen J, Banasik K, Birger Pedersen O et al. Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity. 2019 Jul;79:152-158. https://doi.org/10.1016/j.bbi.2019.01.026

Author

Sølvsten Burgdorf, Kristoffer ; Trabjerg, Betina ; Giørtz Pedersen, Marianne ; Nissen, Janna ; Banasik, Karina ; Birger Pedersen, Ole ; Sørensen, Erik ; René Nielsen, Kaspar ; Hørup Larsen, Margit ; Erikstrup, Christian ; Bruun-Rasmussen, Peter ; Westergaard, David ; Wegner Thørner, Lise ; Hjalgrim, Henrik ; Martina Paarup, Helene ; Brunak, Søren ; Pedersen, Carsten B ; Fuller Torrey, E ; Werge, Thomas ; Bo Mortensen, Preben ; Yolken, Robert ; Ullum, Henrik. / Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. In: Brain, Behavior, and Immunity. 2019 ; Vol. 79. pp. 152-158.

Bibtex

@article{0fdfc068b15149698cfa60282d970f05,
title = "Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders",
abstract = "BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9{\%} of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95{\%} confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95{\%} CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95{\%} CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8{\%} of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95{\%} CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95{\%} CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95{\%} CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95{\%} CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95{\%} CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95{\%} CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.",
keywords = "Antibodies, Cytomegalovirus, Infection, Parasite, psychiatric disorders, Serology, Suicide, Toxoplasma gondii, Toxoplasmosis, Traffic accidents",
author = "{S{\o}lvsten Burgdorf}, Kristoffer and Betina Trabjerg and {Gi{\o}rtz Pedersen}, Marianne and Janna Nissen and Karina Banasik and {Birger Pedersen}, Ole and Erik S{\o}rensen and {Ren{\'e} Nielsen}, Kaspar and {H{\o}rup Larsen}, Margit and Christian Erikstrup and Peter Bruun-Rasmussen and David Westergaard and {Wegner Th{\o}rner}, Lise and Henrik Hjalgrim and {Martina Paarup}, Helene and S{\o}ren Brunak and Pedersen, {Carsten B} and {Fuller Torrey}, E and Thomas Werge and {Bo Mortensen}, Preben and Robert Yolken and Henrik Ullum",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "7",
doi = "10.1016/j.bbi.2019.01.026",
language = "English",
volume = "79",
pages = "152--158",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

AU - Sølvsten Burgdorf, Kristoffer

AU - Trabjerg, Betina

AU - Giørtz Pedersen, Marianne

AU - Nissen, Janna

AU - Banasik, Karina

AU - Birger Pedersen, Ole

AU - Sørensen, Erik

AU - René Nielsen, Kaspar

AU - Hørup Larsen, Margit

AU - Erikstrup, Christian

AU - Bruun-Rasmussen, Peter

AU - Westergaard, David

AU - Wegner Thørner, Lise

AU - Hjalgrim, Henrik

AU - Martina Paarup, Helene

AU - Brunak, Søren

AU - Pedersen, Carsten B

AU - Fuller Torrey, E

AU - Werge, Thomas

AU - Bo Mortensen, Preben

AU - Yolken, Robert

AU - Ullum, Henrik

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

AB - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N=2,591), have attempted or committed suicide (N=655), or have had traffic accidents (N=2,724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

KW - Antibodies

KW - Cytomegalovirus

KW - Infection

KW - Parasite, psychiatric disorders

KW - Serology

KW - Suicide

KW - Toxoplasma gondii

KW - Toxoplasmosis

KW - Traffic accidents

UR - http://www.scopus.com/inward/record.url?scp=85061158198&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2019.01.026

DO - 10.1016/j.bbi.2019.01.026

M3 - Journal article

C2 - 30685531

VL - 79

SP - 152

EP - 158

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -