Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review

Vinni Faber Rasmussen; Troels Staehelin Jensen; Hatice Tankisi; Páll Karlsson; Esben Thyssen Vestergaard; Kurt Kristensen; Jens Randel Nyengaard; Astrid Juhl Terkelsen

doi:10.1016/j.jdiacomp.2021.108027

Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review

Vinni Faber Rasmussen^*, Troels Staehelin Jensen, Hatice Tankisi, Páll Karlsson, Esben Thyssen Vestergaard, Kurt Kristensen, Jens Randel Nyengaard, Astrid Juhl Terkelsen

^*Corresponding author for this work

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Abstract

AIMS: To estimate the prevalence of neuropathy in adolescents with type 1 diabetes.

METHODS: Systematic collection of published studies exploring the prevalence of large fibre neuropathy (LFN), small fibre neuropathy (SFN), and autonomic neuropathy in adolescents with type 1 diabetes. Following prospective registration (Prospero CRD42020206093), PubMed, EMBASE, and Cochrane Library were searched for studies from 2000 to 2020. PICO framework was used in the selection process (Population: adolescents aged 10-19 years with type 1 diabetes; Intervention: diagnostic methods for neuropathy; Comparison: reference data; Outcome: data on prevalence or comparison). Data were extracted concerning study quality based on available data and established methods for determining and diagnosing various neuropathy types.

RESULTS: From 2,017 initial citations, 27 studies (7589 participants) fulfilled eligibility criteria. The study population (47% males) had a diabetes duration between 4.0 and 10.6 years, and HbA1c level between 7.3 and 10.8%, 56-95 mmol/mol. The prevalence of LFN, based on nerve conduction studies, was 10-57%. Based on other tests for neuropathy, the prevalence of LFN and SFN was 12-62%, and that of cardiac autonomic neuropathy was 12-75%.

CONCLUSION: The described prevalence of neuropathy in adolescents with type 1 diabetes varied, which can be methodological due to different screening methods and classifications of neuropathy.

Original language	English
Article number	108027
Journal	Journal of Diabetes and its Complications
Volume	35
Issue	11
Number of pages	10
ISSN	1056-8727
DOIs	https://doi.org/10.1016/j.jdiacomp.2021.108027
Publication status	Published - Nov 2021

Keywords

Adolescents
Neuropathy
Type 1 diabetes
TESTS
GERMAN RESEARCH NETWORK
MICROVASCULAR COMPLICATIONS
CHILDREN
PERIPHERAL-NERVE FUNCTION
NORMAL RANGES
HEART-RATE-VARIABILITY
YOUNG-PEOPLE
CORNEAL CONFOCAL MICROSCOPY
DIAGNOSTIC-CRITERIA

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@article{446a596fc2ae4b63a12f0c53b7ff4873,

title = "Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review",

abstract = "AIMS: To estimate the prevalence of neuropathy in adolescents with type 1 diabetes.METHODS: Systematic collection of published studies exploring the prevalence of large fibre neuropathy (LFN), small fibre neuropathy (SFN), and autonomic neuropathy in adolescents with type 1 diabetes. Following prospective registration (Prospero CRD42020206093), PubMed, EMBASE, and Cochrane Library were searched for studies from 2000 to 2020. PICO framework was used in the selection process (Population: adolescents aged 10-19 years with type 1 diabetes; Intervention: diagnostic methods for neuropathy; Comparison: reference data; Outcome: data on prevalence or comparison). Data were extracted concerning study quality based on available data and established methods for determining and diagnosing various neuropathy types.RESULTS: From 2,017 initial citations, 27 studies (7589 participants) fulfilled eligibility criteria. The study population (47% males) had a diabetes duration between 4.0 and 10.6 years, and HbA1c level between 7.3 and 10.8%, 56-95 mmol/mol. The prevalence of LFN, based on nerve conduction studies, was 10-57%. Based on other tests for neuropathy, the prevalence of LFN and SFN was 12-62%, and that of cardiac autonomic neuropathy was 12-75%.CONCLUSION: The described prevalence of neuropathy in adolescents with type 1 diabetes varied, which can be methodological due to different screening methods and classifications of neuropathy.",

keywords = "Adolescents, Neuropathy, Type 1 diabetes, TESTS, GERMAN RESEARCH NETWORK, MICROVASCULAR COMPLICATIONS, CHILDREN, PERIPHERAL-NERVE FUNCTION, NORMAL RANGES, HEART-RATE-VARIABILITY, YOUNG-PEOPLE, CORNEAL CONFOCAL MICROSCOPY, DIAGNOSTIC-CRITERIA",

author = "Rasmussen, {Vinni Faber} and Jensen, {Troels Staehelin} and Hatice Tankisi and P{\'a}ll Karlsson and Vestergaard, {Esben Thyssen} and Kurt Kristensen and Nyengaard, {Jens Randel} and Terkelsen, {Astrid Juhl}",

year = "2021",

month = nov,

doi = "10.1016/j.jdiacomp.2021.108027",

language = "English",

volume = "35",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "11",

}

Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review. / Rasmussen, Vinni Faber ; Jensen, Troels Staehelin ; Tankisi, Hatice et al.
In: Journal of Diabetes and its Complications, Vol. 35, No. 11, 108027, 11.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

TY - JOUR

T1 - Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes

T2 - A systematic review

AU - Rasmussen, Vinni Faber

AU - Jensen, Troels Staehelin

AU - Tankisi, Hatice

AU - Karlsson, Páll

AU - Vestergaard, Esben Thyssen

AU - Kristensen, Kurt

AU - Nyengaard, Jens Randel

AU - Terkelsen, Astrid Juhl

PY - 2021/11

Y1 - 2021/11

N2 - AIMS: To estimate the prevalence of neuropathy in adolescents with type 1 diabetes.METHODS: Systematic collection of published studies exploring the prevalence of large fibre neuropathy (LFN), small fibre neuropathy (SFN), and autonomic neuropathy in adolescents with type 1 diabetes. Following prospective registration (Prospero CRD42020206093), PubMed, EMBASE, and Cochrane Library were searched for studies from 2000 to 2020. PICO framework was used in the selection process (Population: adolescents aged 10-19 years with type 1 diabetes; Intervention: diagnostic methods for neuropathy; Comparison: reference data; Outcome: data on prevalence or comparison). Data were extracted concerning study quality based on available data and established methods for determining and diagnosing various neuropathy types.RESULTS: From 2,017 initial citations, 27 studies (7589 participants) fulfilled eligibility criteria. The study population (47% males) had a diabetes duration between 4.0 and 10.6 years, and HbA1c level between 7.3 and 10.8%, 56-95 mmol/mol. The prevalence of LFN, based on nerve conduction studies, was 10-57%. Based on other tests for neuropathy, the prevalence of LFN and SFN was 12-62%, and that of cardiac autonomic neuropathy was 12-75%.CONCLUSION: The described prevalence of neuropathy in adolescents with type 1 diabetes varied, which can be methodological due to different screening methods and classifications of neuropathy.

AB - AIMS: To estimate the prevalence of neuropathy in adolescents with type 1 diabetes.METHODS: Systematic collection of published studies exploring the prevalence of large fibre neuropathy (LFN), small fibre neuropathy (SFN), and autonomic neuropathy in adolescents with type 1 diabetes. Following prospective registration (Prospero CRD42020206093), PubMed, EMBASE, and Cochrane Library were searched for studies from 2000 to 2020. PICO framework was used in the selection process (Population: adolescents aged 10-19 years with type 1 diabetes; Intervention: diagnostic methods for neuropathy; Comparison: reference data; Outcome: data on prevalence or comparison). Data were extracted concerning study quality based on available data and established methods for determining and diagnosing various neuropathy types.RESULTS: From 2,017 initial citations, 27 studies (7589 participants) fulfilled eligibility criteria. The study population (47% males) had a diabetes duration between 4.0 and 10.6 years, and HbA1c level between 7.3 and 10.8%, 56-95 mmol/mol. The prevalence of LFN, based on nerve conduction studies, was 10-57%. Based on other tests for neuropathy, the prevalence of LFN and SFN was 12-62%, and that of cardiac autonomic neuropathy was 12-75%.CONCLUSION: The described prevalence of neuropathy in adolescents with type 1 diabetes varied, which can be methodological due to different screening methods and classifications of neuropathy.

KW - Adolescents

KW - Neuropathy

KW - Type 1 diabetes

KW - TESTS

KW - GERMAN RESEARCH NETWORK

KW - MICROVASCULAR COMPLICATIONS

KW - CHILDREN

KW - PERIPHERAL-NERVE FUNCTION

KW - NORMAL RANGES

KW - HEART-RATE-VARIABILITY

KW - YOUNG-PEOPLE

KW - CORNEAL CONFOCAL MICROSCOPY

KW - DIAGNOSTIC-CRITERIA

U2 - 10.1016/j.jdiacomp.2021.108027

DO - 10.1016/j.jdiacomp.2021.108027

M3 - Review

C2 - 34429229

SN - 1056-8727

VL - 35

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 11

M1 - 108027

ER -

Large fibre, small fibre and autonomic neuropathy in adolescents with type 1 diabetes: A systematic review

Abstract

Keywords

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