Aarhus University Seal

Lack of consideration of sex and gender in COVID-19 clinical studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Emer Brady
  • M. W Nielsen, University of Copenhagen, Denmark
  • Jens Peter Andersen
  • S. Oertelt-Prigione, Bielefeld University, Radboud University Nijmegen, Netherlands

Sex and gender differences impact the incidence of SARS-CoV-2 infection and COVID-19 mortality. Furthermore, sex differences influence the frequency and severity of pharmacological side effects. A large number of clinical trials to develop new therapeutic approaches and vaccines for COVID-19 are ongoing. We investigated the inclusion of sex and/or gender in COVID-19 studies on ClinicalTrials.gov, collecting data for the period January 1, 2020 to January 26, 2021. Here, we show that of the 4,420 registered SARS-CoV-2/COVID-19 studies, 935 (21.2%) address sex/gender solely in the context of recruitment, 237 (5.4%) plan sex-matched or representative samples or emphasized sex/gender reporting, and only 178 (4%) explicitly report a plan to include sex/gender as an analytical variable. Just eight (17.8%) of the 45 COVID-19 related clinical trials published in scientific journals until December 15, 2020 report sex-disaggregated results or subgroup analyses.

Original languageEnglish
Article number4015
JournalNature Communications
Publication statusPublished - Jul 2021

See relations at Aarhus University Citationformats

ID: 219395490