Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics

TY - JOUR

T1 - Key Signaling Pathways in Psoriasis

T2 - Recent Insights from Antipsoriatic Therapeutics

AU - Ben Abdallah, Hakim

AU - Johansen, Claus

AU - Iversen, Lars

PY - 2021/6

Y1 - 2021/6

N2 - Psoriasis is a common chronic inflammatory skin disease associated with several comorbidities and reduced quality of life. In the past decades, highly effective targeted therapies have led to breakthroughs in the management of psoriasis, providing important insights into the pathogenesis. This article reviews the current concepts of the pathophysiological pathways and the recent progress in antipsoriatic therapeutics, highlighting key targets, signaling pathways and clinical effects in psoriasis.

AB - Psoriasis is a common chronic inflammatory skin disease associated with several comorbidities and reduced quality of life. In the past decades, highly effective targeted therapies have led to breakthroughs in the management of psoriasis, providing important insights into the pathogenesis. This article reviews the current concepts of the pathophysiological pathways and the recent progress in antipsoriatic therapeutics, highlighting key targets, signaling pathways and clinical effects in psoriasis.

U2 - 10.2147/PTT.S294173

DO - 10.2147/PTT.S294173

M3 - Review

C2 - 34235053

SN - 2230-326X

VL - 11

SP - 83

EP - 97

JO - Psoriasis: Targets and Therapy

JF - Psoriasis: Targets and Therapy

ER -