Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance

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Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance. / Høgild, Morten Lyng; Hjelholt, Astrid Johannesson; Hansen, Jakob et al.

In: The Journal of clinical endocrinology and metabolism, Vol. 108, No. 3, 03.2023.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Høgild ML, Hjelholt AJ, Hansen J, Pedersen SB, Møller N, Wojtaszewski JFP et al. Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance. The Journal of clinical endocrinology and metabolism. 2023 Mar;108(3). doi: 10.1210/clinem/dgac595

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@article{ea7429e3b1dd45fea47e1448b31bab75,
title = "Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance",
abstract = "BACKGROUND: Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain. We tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels.DESIGN: In a randomized, single-blinded crossover design, eight healthy men were studied twice with a GH infusion to induce lipolysis in combination with infusion of either βOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies.RESULTS: βOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both βOHB and its derivative acetoacetate.CONCLUSION: Our data unravel an insulin sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis.",
author = "H{\o}gild, {Morten Lyng} and Hjelholt, {Astrid Johannesson} and Jakob Hansen and Pedersen, {Steen B{\o}nl{\o}kke} and Niels M{\o}ller and Wojtaszewski, {J{\o}rgen F P} and Mogens Johannsen and Niels Jessen and {Lunde J{\o}rgensen}, {Jens Otto}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2023",
month = mar,
doi = "10.1210/clinem/dgac595",
language = "English",
volume = "108",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance

AU - Høgild, Morten Lyng

AU - Hjelholt, Astrid Johannesson

AU - Hansen, Jakob

AU - Pedersen, Steen Bønløkke

AU - Møller, Niels

AU - Wojtaszewski, Jørgen F P

AU - Johannsen, Mogens

AU - Jessen, Niels

AU - Lunde Jørgensen, Jens Otto

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2023/3

Y1 - 2023/3

N2 - BACKGROUND: Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain. We tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels.DESIGN: In a randomized, single-blinded crossover design, eight healthy men were studied twice with a GH infusion to induce lipolysis in combination with infusion of either βOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies.RESULTS: βOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both βOHB and its derivative acetoacetate.CONCLUSION: Our data unravel an insulin sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis.

AB - BACKGROUND: Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain. We tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels.DESIGN: In a randomized, single-blinded crossover design, eight healthy men were studied twice with a GH infusion to induce lipolysis in combination with infusion of either βOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies.RESULTS: βOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both βOHB and its derivative acetoacetate.CONCLUSION: Our data unravel an insulin sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis.

U2 - 10.1210/clinem/dgac595

DO - 10.1210/clinem/dgac595

M3 - Journal article

C2 - 36240323

VL - 108

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -