Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

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Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. / Antila, Hanna; Ryazantseva, Maria; Popova, Dina; Sipilä, Pia; Guirado, Ramon; Kohtala, Samuel; Yalcin, Ipek; Lindholm, Jesse; Vesa, Liisa; Sato, Vinicius; Cordeira, Joshua; Autio, Henri; Kislin, Mikhail; Rios, Maribel; Joca, Sâmia; Casarotto, Plinio; Khiroug, Leonard; Lauri, Sari; Taira, Tomi; Castrén, Eero; Rantamäki, Tomi.

In: Scientific Reports, Vol. 7, No. 1, 10.08.2017, p. 7811.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Antila, H, Ryazantseva, M, Popova, D, Sipilä, P, Guirado, R, Kohtala, S, Yalcin, I, Lindholm, J, Vesa, L, Sato, V, Cordeira, J, Autio, H, Kislin, M, Rios, M, Joca, S, Casarotto, P, Khiroug, L, Lauri, S, Taira, T, Castrén, E & Rantamäki, T 2017, 'Isoflurane produces antidepressant effects and induces TrkB signaling in rodents', Scientific Reports, vol. 7, no. 1, pp. 7811. https://doi.org/10.1038/s41598-017-08166-9

APA

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., ... Rantamäki, T. (2017). Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports, 7(1), 7811. https://doi.org/10.1038/s41598-017-08166-9

CBE

Antila H, Ryazantseva M, Popova D, Sipilä P, Guirado R, Kohtala S, Yalcin I, Lindholm J, Vesa L, Sato V, Cordeira J, Autio H, Kislin M, Rios M, Joca S, Casarotto P, Khiroug L, Lauri S, Taira T, Castrén E, Rantamäki T. 2017. Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports. 7(1):7811. https://doi.org/10.1038/s41598-017-08166-9

MLA

Vancouver

Antila H, Ryazantseva M, Popova D, Sipilä P, Guirado R, Kohtala S et al. Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports. 2017 Aug 10;7(1):7811. https://doi.org/10.1038/s41598-017-08166-9

Author

Antila, Hanna ; Ryazantseva, Maria ; Popova, Dina ; Sipilä, Pia ; Guirado, Ramon ; Kohtala, Samuel ; Yalcin, Ipek ; Lindholm, Jesse ; Vesa, Liisa ; Sato, Vinicius ; Cordeira, Joshua ; Autio, Henri ; Kislin, Mikhail ; Rios, Maribel ; Joca, Sâmia ; Casarotto, Plinio ; Khiroug, Leonard ; Lauri, Sari ; Taira, Tomi ; Castrén, Eero ; Rantamäki, Tomi. / Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. In: Scientific Reports. 2017 ; Vol. 7, No. 1. pp. 7811.

Bibtex

@article{a7112707b5b14600a22ff63d3002e388,
title = "Isoflurane produces antidepressant effects and induces TrkB signaling in rodents",
abstract = "A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.",
keywords = "Journal Article",
author = "Hanna Antila and Maria Ryazantseva and Dina Popova and Pia Sipil{\"a} and Ramon Guirado and Samuel Kohtala and Ipek Yalcin and Jesse Lindholm and Liisa Vesa and Vinicius Sato and Joshua Cordeira and Henri Autio and Mikhail Kislin and Maribel Rios and S{\^a}mia Joca and Plinio Casarotto and Leonard Khiroug and Sari Lauri and Tomi Taira and Eero Castr{\'e}n and Tomi Rantam{\"a}ki",
year = "2017",
month = "8",
day = "10",
doi = "10.1038/s41598-017-08166-9",
language = "English",
volume = "7",
pages = "7811",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

AU - Antila, Hanna

AU - Ryazantseva, Maria

AU - Popova, Dina

AU - Sipilä, Pia

AU - Guirado, Ramon

AU - Kohtala, Samuel

AU - Yalcin, Ipek

AU - Lindholm, Jesse

AU - Vesa, Liisa

AU - Sato, Vinicius

AU - Cordeira, Joshua

AU - Autio, Henri

AU - Kislin, Mikhail

AU - Rios, Maribel

AU - Joca, Sâmia

AU - Casarotto, Plinio

AU - Khiroug, Leonard

AU - Lauri, Sari

AU - Taira, Tomi

AU - Castrén, Eero

AU - Rantamäki, Tomi

PY - 2017/8/10

Y1 - 2017/8/10

N2 - A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.

AB - A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.

KW - Journal Article

U2 - 10.1038/s41598-017-08166-9

DO - 10.1038/s41598-017-08166-9

M3 - Journal article

C2 - 28798343

VL - 7

SP - 7811

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -