Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Frederik Faergemann Lau, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.
  • ,
  • Signe Bollerup, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.
  • ,
  • Frederik Engsig, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.
  • ,
  • Henrik Krarup, Department of Molecular Diagnostics, Aalborg University, Aalborg, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Lone Hagens Mygind, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Jesper Bach Hansen, Department of Medical Gastroenterology, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Lone Galmstrup Madsen, Reviewer - Academic Assessments - Zealand University Hospital, Region Zealand
  • ,
  • Peter Thielsen, Herlev Hospital, University of Copenhagen, Herlev
  • ,
  • Ulla Balslev, Herlev Hospital, University of Copenhagen, Herlev
  • ,
  • Lars Nørregaard Nielsen, Nordsjællands Hospital, Department of Lung Medicine and Infectious Diseases, Hillerød 3400, Denmark., Department of Pediatrics, North Zealand Hospital Hilleroed, Hilleroed.
  • ,
  • Toke S Barfod, Reviewer - Academic Assessments - Zealand University Hospital, Region Zealand
  • ,
  • Mette Rye Clausen, aDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark bViro-Immunology Research Unit cDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen dDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus eDepartment of Infectious Diseases, Hvidovre, Copenhagen University Hospital, Copenhagen fDepartment of Infectious Diseases, Odense University Hospital, Odense gDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
  • ,
  • Lise Hobolth, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.
  • ,
  • Alex Lund Laursen
  • Britta Tarp
  • Birgit T Roege, Department of Pediatrics, Kolding Hospital, Kolding, Denmark
  • ,
  • Jan Gerstoft, aDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark bViro-Immunology Research Unit cDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen dDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus eDepartment of Infectious Diseases, Hvidovre, Copenhagen University Hospital, Copenhagen fDepartment of Infectious Diseases, Odense University Hospital, Odense gDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
  • ,
  • Peer Brehm Christensen, HCA Hospital for Children, University of Southern Denmark, Odense University Hospital, Odense, Denmark., Clinical Cell Biology, Research Unit of Pathology, Department of Clinical Research, University of Southern Denmark and Department of Pathology, Odense University Hospital, Odense, Denmark; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Clinical Cell Biology, Vejle Hospital - Lillebælt Hospital, University of Southern Denmark, Vejle, Denmark; Department of Forensic Medicine, Aarhus University, Aarhus, Denmark. Electronic address: thomas.levin.andersen@rsyd.dk.
  • ,
  • Nina Weis, Department of Ambulatory Surgery, Hvidovre Hospital, Copenhagen University Hospital, Kettegårdsalle 30, 2650 Hvidovre, Copenhagen, Denmark.

Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.

Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.

Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).

Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

Original languageEnglish
JournalClinical epidemiology
Volume14
Pages (from-to)879-888
Number of pages10
ISSN1179-1349
DOIs
Publication statusPublished - 2022

Bibliographical note

© 2022 Lau et al.

See relations at Aarhus University Citationformats

ID: 277651409