Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Is population screening for abdominal aortic aneurysm cost-effective?
AU - Ehlers, Lars
AU - Sørensen, Jan
AU - Jensen, Lotte Groth
AU - Bech, Merete
AU - Kjølby, Mette
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Ruptured abdominal aortic aneurysm (AAA) is responsible for 1-2% of all male deaths over the age of 65 years. Early detection of AAA and elective surgery can reduce the mortality risk associated with AAA. However, many patients will not be diagnosed with AAA and have therefore an increased death risk due to the untreated AAA. It has been suggested that population screening for AAA in elderly males is effective and cost-effective. The purpose of this study was to perform a systematic review of published cost-effectiveness analyses of screening elderly men for AAA.METHODS: We performed a systematic search for economic evaluations in NHSEED, EconLit, Medline, Cochrane, Embase, Cinahl and two Scandinavian HTA data bases (DACEHTA and SBU). All identified studies were read in full and each study was systematically assessed according to international guidelines for critical assessment of economic evaluations in health care.RESULTS: The search identified 16 cost-effectiveness studies. Most studies considered only short term cost consequences. The studies seemed to employ a number of "optimistic" assumptions in favour of AAA screening, and included only few sensitivity analyses that assessed less optimistic assumptions.CONCLUSION: Further analyses of cost-effectiveness of AAA screening are recommended.
AB - BACKGROUND: Ruptured abdominal aortic aneurysm (AAA) is responsible for 1-2% of all male deaths over the age of 65 years. Early detection of AAA and elective surgery can reduce the mortality risk associated with AAA. However, many patients will not be diagnosed with AAA and have therefore an increased death risk due to the untreated AAA. It has been suggested that population screening for AAA in elderly males is effective and cost-effective. The purpose of this study was to perform a systematic review of published cost-effectiveness analyses of screening elderly men for AAA.METHODS: We performed a systematic search for economic evaluations in NHSEED, EconLit, Medline, Cochrane, Embase, Cinahl and two Scandinavian HTA data bases (DACEHTA and SBU). All identified studies were read in full and each study was systematically assessed according to international guidelines for critical assessment of economic evaluations in health care.RESULTS: The search identified 16 cost-effectiveness studies. Most studies considered only short term cost consequences. The studies seemed to employ a number of "optimistic" assumptions in favour of AAA screening, and included only few sensitivity analyses that assessed less optimistic assumptions.CONCLUSION: Further analyses of cost-effectiveness of AAA screening are recommended.
KW - Aged
KW - Aged, 80 and over
KW - Aortic Aneurysm, Abdominal
KW - Aortic Rupture
KW - Cost-Benefit Analysis
KW - Decision Making, Computer-Assisted
KW - Female
KW - Hospital Costs
KW - Humans
KW - Male
KW - Mass Screening
KW - Middle Aged
KW - Quality of Life
KW - Smoking Cessation
KW - Ultrasonography
U2 - 10.1186/1471-2261-8-32
DO - 10.1186/1471-2261-8-32
M3 - Journal article
C2 - 19017393
VL - 8
SP - 32
JO - B M C Cardiovascular Disorders
JF - B M C Cardiovascular Disorders
SN - 1471-2261
ER -