Is endometriosis associated with irritable bowel syndrome? A cross-sectional study

Mia Schomacker; Karina Ejgaard Hansen; Cecilia Ramlau-Hansen; Axel Forman

doi:10.1016/j.ejogrb.2018.10.023

Is endometriosis associated with irritable bowel syndrome? A cross-sectional study

Mia Schomacker, Karina Ejgaard Hansen, Cecilia Ramlau-Hansen, Axel Forman

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

31 Citations (Scopus)

Abstract

Objectives: Previous studies have found a high prevalence of irritable bowel syndrome (IBS). However, data on this relation in women without bowel endometriosis is limited. The aim of this study was to compare the prevalence of IBS in women with endometriosis to the prevalence in women without endometriosis and to investigate if the prevalence of IBS was associated with bowel involved endometriosis. Study design: Information for this cross-sectional study was collected through an online questionnaire. A total of 373 women completed the questionnaire. After exclusions, 254 with endometriosis and 102 without endometriosis were included (N = 356). Endometriosis was identified by self-reported diagnosis. IBS was identified by; 1. self-reported diagnosis prior to the study and 2. fulfillment of ROME III diagnostic criteria in this study. Odds ratios were calculated to estimate the strength of the association between IBS and endometriosis. A separate analysis, restricted to women without bowel involved endometrioses, was conducted. Adjustment for potential confounders (age, gastroenterological comorbidities and length of education) was performed. Results and conclusions: The prevalence of IBS was higher in women with endometriosis compared to the women without endometriosis (OR = 5.32 (CI: 2.88; 9.81)). In the analysis restricted to women without bowel involved endometriosis, the prevalence was also higher in women with endometriosis compared to women without endometriosis (OR = 6.54 (CI95% 3.22; 13.29)). Thus, this study found a higher prevalence of IBS in women with endometriosis compared to women without endometriosis. This finding seems to be unrelated to bowel involvement. This opens new perspectives in relation to treatment of endometriosis.

Original language	English
Journal	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume	231
Pages (from-to)	65-69
Number of pages	5
ISSN	0301-2115
DOIs	https://doi.org/10.1016/j.ejogrb.2018.10.023
Publication status	Published - 2018

Keywords

Comorbidity
Endometriosis
Irritable bowel syndrome
Misdiagnosis
Pelvic pain

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10.1016/j.ejogrb.2018.10.023

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title = "Is endometriosis associated with irritable bowel syndrome? A cross-sectional study",

abstract = "Objectives: Previous studies have found a high prevalence of irritable bowel syndrome (IBS). However, data on this relation in women without bowel endometriosis is limited. The aim of this study was to compare the prevalence of IBS in women with endometriosis to the prevalence in women without endometriosis and to investigate if the prevalence of IBS was associated with bowel involved endometriosis. Study design: Information for this cross-sectional study was collected through an online questionnaire. A total of 373 women completed the questionnaire. After exclusions, 254 with endometriosis and 102 without endometriosis were included (N = 356). Endometriosis was identified by self-reported diagnosis. IBS was identified by; 1. self-reported diagnosis prior to the study and 2. fulfillment of ROME III diagnostic criteria in this study. Odds ratios were calculated to estimate the strength of the association between IBS and endometriosis. A separate analysis, restricted to women without bowel involved endometrioses, was conducted. Adjustment for potential confounders (age, gastroenterological comorbidities and length of education) was performed. Results and conclusions: The prevalence of IBS was higher in women with endometriosis compared to the women without endometriosis (OR = 5.32 (CI: 2.88; 9.81)). In the analysis restricted to women without bowel involved endometriosis, the prevalence was also higher in women with endometriosis compared to women without endometriosis (OR = 6.54 (CI95% 3.22; 13.29)). Thus, this study found a higher prevalence of IBS in women with endometriosis compared to women without endometriosis. This finding seems to be unrelated to bowel involvement. This opens new perspectives in relation to treatment of endometriosis.",

keywords = "Comorbidity, Endometriosis, Irritable bowel syndrome, Misdiagnosis, Pelvic pain",

author = "Mia Schomacker and Hansen, {Karina Ejgaard} and Cecilia Ramlau-Hansen and Axel Forman",

year = "2018",

doi = "10.1016/j.ejogrb.2018.10.023",

language = "English",

volume = "231",

pages = "65--69",

journal = "European Journal of Obstetrics & Gynecology and Reproductive Biology",

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}

Is endometriosis associated with irritable bowel syndrome? A cross-sectional study. / Schomacker, Mia; Hansen, Karina Ejgaard ; Ramlau-Hansen, Cecilia et al.
In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 231, 2018, p. 65-69.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Is endometriosis associated with irritable bowel syndrome? A cross-sectional study

AU - Schomacker, Mia

AU - Hansen, Karina Ejgaard

AU - Ramlau-Hansen, Cecilia

AU - Forman, Axel

PY - 2018

Y1 - 2018

N2 - Objectives: Previous studies have found a high prevalence of irritable bowel syndrome (IBS). However, data on this relation in women without bowel endometriosis is limited. The aim of this study was to compare the prevalence of IBS in women with endometriosis to the prevalence in women without endometriosis and to investigate if the prevalence of IBS was associated with bowel involved endometriosis. Study design: Information for this cross-sectional study was collected through an online questionnaire. A total of 373 women completed the questionnaire. After exclusions, 254 with endometriosis and 102 without endometriosis were included (N = 356). Endometriosis was identified by self-reported diagnosis. IBS was identified by; 1. self-reported diagnosis prior to the study and 2. fulfillment of ROME III diagnostic criteria in this study. Odds ratios were calculated to estimate the strength of the association between IBS and endometriosis. A separate analysis, restricted to women without bowel involved endometrioses, was conducted. Adjustment for potential confounders (age, gastroenterological comorbidities and length of education) was performed. Results and conclusions: The prevalence of IBS was higher in women with endometriosis compared to the women without endometriosis (OR = 5.32 (CI: 2.88; 9.81)). In the analysis restricted to women without bowel involved endometriosis, the prevalence was also higher in women with endometriosis compared to women without endometriosis (OR = 6.54 (CI95% 3.22; 13.29)). Thus, this study found a higher prevalence of IBS in women with endometriosis compared to women without endometriosis. This finding seems to be unrelated to bowel involvement. This opens new perspectives in relation to treatment of endometriosis.

AB - Objectives: Previous studies have found a high prevalence of irritable bowel syndrome (IBS). However, data on this relation in women without bowel endometriosis is limited. The aim of this study was to compare the prevalence of IBS in women with endometriosis to the prevalence in women without endometriosis and to investigate if the prevalence of IBS was associated with bowel involved endometriosis. Study design: Information for this cross-sectional study was collected through an online questionnaire. A total of 373 women completed the questionnaire. After exclusions, 254 with endometriosis and 102 without endometriosis were included (N = 356). Endometriosis was identified by self-reported diagnosis. IBS was identified by; 1. self-reported diagnosis prior to the study and 2. fulfillment of ROME III diagnostic criteria in this study. Odds ratios were calculated to estimate the strength of the association between IBS and endometriosis. A separate analysis, restricted to women without bowel involved endometrioses, was conducted. Adjustment for potential confounders (age, gastroenterological comorbidities and length of education) was performed. Results and conclusions: The prevalence of IBS was higher in women with endometriosis compared to the women without endometriosis (OR = 5.32 (CI: 2.88; 9.81)). In the analysis restricted to women without bowel involved endometriosis, the prevalence was also higher in women with endometriosis compared to women without endometriosis (OR = 6.54 (CI95% 3.22; 13.29)). Thus, this study found a higher prevalence of IBS in women with endometriosis compared to women without endometriosis. This finding seems to be unrelated to bowel involvement. This opens new perspectives in relation to treatment of endometriosis.

KW - Comorbidity

KW - Endometriosis

KW - Irritable bowel syndrome

KW - Misdiagnosis

KW - Pelvic pain

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U2 - 10.1016/j.ejogrb.2018.10.023

DO - 10.1016/j.ejogrb.2018.10.023

M3 - Journal article

C2 - 30326376

SN - 0301-2115

VL - 231

SP - 65

EP - 69

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

ER -

Is endometriosis associated with irritable bowel syndrome? A cross-sectional study

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