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Investigating the causal relationship between neuroticism and depression via Mendelian Randomization

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  • Doug Speed
  • Gibran Hemani, Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, UK.
  • ,
  • Maria S Speed
  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
  • ,
  • Anders D Børglum

Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect [1]. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Pages (from-to)395-397
Number of pages3
Publication statusPublished - 2019

Bibliographical note

This article is protected by copyright. All rights reserved.

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