TY - JOUR
T1 - Investigating the causal relationship between neuroticism and depression via Mendelian Randomization
AU - Speed, Doug
AU - Hemani, Gibran
AU - Speed, Maria S
AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
AU - Børglum, Anders D
AU - Østergaard, Søren D
AU - Christensen, Jane Hvarregaard
AU - Buttenschøn, Henriette Nørmølle
AU - Mortensen, Preben Bo
AU - Grove, Jakob
AU - Qvist, Per
N1 - This article is protected by copyright. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect [1]. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression. This article is protected by copyright. All rights reserved.
AB - Neuroticism is a heritable personality trait, characterized by negative emotions such as worrying, feelings of guilt, loneliness and being easily hurt. Increased levels of neuroticism are associated with poor mental health - development of depression in particular - but it remains uncertain whether this association represents a causal effect [1]. Here, we use Mendelian randomization (MR) to investigate whether neuroticism is a causal risk factor for development of depression. This article is protected by copyright. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=85061836520&partnerID=8YFLogxK
U2 - 10.1111/acps.13009
DO - 10.1111/acps.13009
M3 - Letter
C2 - 30697695
SN - 0001-690X
VL - 139
SP - 395
EP - 397
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - 4
ER -