Introduction of cryobiopsies in the diagnostics of interstitial lung diseases - experiences in a referral center

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  • Sissel Kronborg-White
  • ,
  • Birgitte Folkersen, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
  • ,
  • Torben Riis Rasmussen
  • Nina Voldby, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
  • ,
  • Line Bille Madsen
  • ,
  • Finn Rasmussen
  • ,
  • Venerino Poletti
  • ,
  • Elisabeth Bendstrup

Introduction: Transbronchial cryobiopsies (cTBB) has emerged as a new method for obtaining lung tissue biopsies in the diagnosis of interstitial lung diseases (ILDs). Until now, it has been used in a few highly specialized interventional centers and has shown promising results in obtaining a definite diagnosis of ILDs. Method: All patients undergoing a cTBB between November 2015 and June 2016 were included in this case series study. Data on patient demographics, high-resolution computed tomography patterns, size and number of biopsies, histology patterns, the contribution to a confident diagnosis and complications were registered. Results: Thirty-eight patients underwent cTBB in the period. cTBB contributed to the diagnosis in 28 (74%) of the 38 patients. Only few complications were observed; pneumothorax was the most frequent complication (10 patients, 26%). In six patients, local bleeding occurred during the procedure and was easily controlled by a Fogarty catheter balloon and in some cases tranexamic acid. Conclusion: Performing cTBB in the diagnostics of ILDs is a safe and feasible procedure. cTBB resulted in a confident diagnosis in 74% of cases.

Original languageEnglish
JournalClinical Respiratory Journal
Pages (from-to)1274099
Publication statusPublished - 2017

    Research areas

  • Journal Article

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ID: 116302599