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Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

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  • Interdisciplinary Nanoscience Center
  • Department of Experimental Clinical Oncology
  • Department of Molecular Biology
  • Department of Molecular Biology
One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.
Original languageEnglish
JournalRadiotherapy & Oncology
Pages (from-to)143-8
Number of pages6
Publication statusPublished - 1 Oct 2010

    Research areas

  • Animals, Chitosan, Fibrosis, Injections, Intraperitoneal, Male, Mammary Neoplasms, Experimental, Nanoparticles, RNA, Small Interfering, Radiation Injuries, Rats, Tumor Necrosis Factor-alpha

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