Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Isabel Nawroth; Jan Alsner; Mark A Behlke; Flemming Besenbacher; Jens Overgaard; Kenneth A Howard; Jørgen Kjems

doi:10.1016/j.radonc.2010.09.010

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Isabel Nawroth, Jan Alsner, Mark A Behlke, Flemming Besenbacher, Jens Overgaard, Kenneth A Howard, Jørgen Kjems

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

60 Citations (Scopus)

Abstract

One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.

Original language	English
Journal	Radiotherapy & Oncology
Volume	97
Issue	1
Pages (from-to)	143-8
Number of pages	6
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2010.09.010
Publication status	Published - 1 Oct 2010

Keywords

Animals
Chitosan
Fibrosis
Injections, Intraperitoneal
Male
Mammary Neoplasms, Experimental
Nanoparticles
RNA, Small Interfering
Radiation Injuries
Rats
Tumor Necrosis Factor-alpha

Access to Document

10.1016/j.radonc.2010.09.010

http://www.ncbi.nlm.nih.gov/pubmed/?term=20889220

Cite this

@article{1e6f14b25dcc45f8b754f0a5ab63b634,

title = "Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis",

abstract = "One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.",

keywords = "Animals, Chitosan, Fibrosis, Injections, Intraperitoneal, Male, Mammary Neoplasms, Experimental, Nanoparticles, RNA, Small Interfering, Radiation Injuries, Rats, Tumor Necrosis Factor-alpha",

author = "Isabel Nawroth and Jan Alsner and Behlke, {Mark A} and Flemming Besenbacher and Jens Overgaard and Howard, {Kenneth A} and J{\o}rgen Kjems",

year = "2010",

month = oct,

day = "1",

doi = "10.1016/j.radonc.2010.09.010",

language = "English",

volume = "97",

pages = "143--8",

journal = "Radiotherapy & Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis. / Nawroth, Isabel; Alsner, Jan; Behlke, Mark A et al.
In: Radiotherapy & Oncology, Vol. 97, No. 1, 01.10.2010, p. 143-8.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

AU - Nawroth, Isabel

AU - Alsner, Jan

AU - Behlke, Mark A

AU - Besenbacher, Flemming

AU - Overgaard, Jens

AU - Howard, Kenneth A

AU - Kjems, Jørgen

PY - 2010/10/1

Y1 - 2010/10/1

N2 - One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.

AB - One of the most common and dose-limiting long-term adverse effects of radiation therapy is radiation-induced fibrosis (RIF), which is characterized by restricted tissue flexibility, reduced compliance or strictures, pain and in severe cases, ulceration and necrosis. Several strategies have been proposed to ameliorate RIF but presently no effective one is available. Recent studies have reported that tumor necrosis factor-α (TNFα) plays a role in fibrogenesis.

KW - Animals

KW - Chitosan

KW - Fibrosis

KW - Injections, Intraperitoneal

KW - Male

KW - Mammary Neoplasms, Experimental

KW - Nanoparticles

KW - RNA, Small Interfering

KW - Radiation Injuries

KW - Rats

KW - Tumor Necrosis Factor-alpha

U2 - 10.1016/j.radonc.2010.09.010

DO - 10.1016/j.radonc.2010.09.010

M3 - Journal article

C2 - 20889220

SN - 0167-8140

VL - 97

SP - 143

EP - 148

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 1

ER -

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this