Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

Ellen K. Janke; Silke B. Chalmers; Sarah J. Roberts-Thomson; Gregory R. Monteith

doi:10.1016/j.ceca.2023.102741

Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

Ellen K. Janke, Silke B. Chalmers, Sarah J. Roberts-Thomson, Gregory R. Monteith^*

^*Corresponding author for this work

Department of Biomedicine - Forskning og uddannelse, Skou-bygningen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca²⁺) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca²⁺ signalling and EMT will be explored. An overview of the Ca²⁺ pathways that are remodelled as a consequence of EMT is provided and the role of Ca²⁺ signalling in regulating EMT and its significance is considered. Ca²⁺ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca²⁺ signalling is to be manipulated with the aim of therapeutic intervention in cancer.

Original language	English
Article number	102741
Journal	Cell Calcium
Volume	112
ISSN	0143-4160
DOIs	https://doi.org/10.1016/j.ceca.2023.102741
Publication status	Published - Jun 2023

Keywords

Calcium signalling
Cancer
EMT
Epithelial
Mesenchymal

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10.1016/j.ceca.2023.102741

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title = "Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer",

abstract = "Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca2+) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca2+ signalling and EMT will be explored. An overview of the Ca2+ pathways that are remodelled as a consequence of EMT is provided and the role of Ca2+ signalling in regulating EMT and its significance is considered. Ca2+ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca2+ signalling is to be manipulated with the aim of therapeutic intervention in cancer.",

keywords = "Calcium signalling, Cancer, EMT, Epithelial, Mesenchymal",

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AU - Janke, Ellen K.

AU - Chalmers, Silke B.

AU - Roberts-Thomson, Sarah J.

AU - Monteith, Gregory R.

PY - 2023/6

Y1 - 2023/6

N2 - Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca2+) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca2+ signalling and EMT will be explored. An overview of the Ca2+ pathways that are remodelled as a consequence of EMT is provided and the role of Ca2+ signalling in regulating EMT and its significance is considered. Ca2+ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca2+ signalling is to be manipulated with the aim of therapeutic intervention in cancer.

AB - Epithelial-mesenchymal transition (EMT) is a form of cellular phenotypic plasticity and is considered a crucial step in the progression of many cancers. The calcium ion (Ca2+) acts as a ubiquitous second messenger and is implicated in many cellular processes, including cell death, migration, invasion and more recently EMT. Throughout this review, the complex interplay between Ca2+ signalling and EMT will be explored. An overview of the Ca2+ pathways that are remodelled as a consequence of EMT is provided and the role of Ca2+ signalling in regulating EMT and its significance is considered. Ca2+ signalling pathways may represent a therapeutic opportunity to regulate EMT. However, as will be described in this review, the complexity of these signalling pathways represents significant challenges that must be considered if Ca2+ signalling is to be manipulated with the aim of therapeutic intervention in cancer.

KW - Calcium signalling

KW - Cancer

KW - EMT

KW - Epithelial

KW - Mesenchymal

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JO - Cell Calcium

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Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer

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Keywords

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