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Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers

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Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers. / Finkel, Sebastian; Veit, Ralf; Lotze, Martin; Friberg, Anders; Vuust, Peter; Soekadar, Surjo; Birbaumer, Niels; Kleber, Boris.

In: Human Brain Mapping, Vol. 40, No. 7, 05.2019, p. 2174-2187.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Finkel, S, Veit, R, Lotze, M, Friberg, A, Vuust, P, Soekadar, S, Birbaumer, N & Kleber, B 2019, 'Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers', Human Brain Mapping, vol. 40, no. 7, pp. 2174-2187. https://doi.org/10.1002/hbm.24515

APA

Finkel, S., Veit, R., Lotze, M., Friberg, A., Vuust, P., Soekadar, S., Birbaumer, N., & Kleber, B. (2019). Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers. Human Brain Mapping, 40(7), 2174-2187. https://doi.org/10.1002/hbm.24515

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MLA

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Author

Finkel, Sebastian ; Veit, Ralf ; Lotze, Martin ; Friberg, Anders ; Vuust, Peter ; Soekadar, Surjo ; Birbaumer, Niels ; Kleber, Boris. / Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers. In: Human Brain Mapping. 2019 ; Vol. 40, No. 7. pp. 2174-2187.

Bibtex

@article{879a2ff7427742d094acad9f2421eb7e,
title = "Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers",
abstract = "While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in participants without singing experience. A pitch-matching singing task was performed before and after iTBS to assess corresponding effects on vocal pitch regulation. When participants could monitor auditory feedback from their own voice during singing (Experiment I), no difference in pitch-matching performance was found between iTBS sessions. However, when auditory feedback was masked with noise (Experiment II), only larynx-S1 iTBS enhanced pitch accuracy (50–250 ms after sound onset) and pitch stability (>250 ms after sound onset until the end). Results indicate that somatosensory feedback plays a dominant role in vocal pitch regulation when acoustic feedback is masked. The acoustic changes moreover suggest that right larynx-S1 stimulation affected the preparation and involuntary regulation of vocal pitch accuracy, and that kinesthetic-proprioceptive processes play a role in the voluntary control of pitch stability in nonsingers. Together, these data provide evidence for a causal involvement of right larynx-S1 in vocal pitch regulation during singing.",
keywords = "predictive coding, sensorimotor, singing, TMS, vocal production, MATCHING ACCURACY, AUDITORY-FEEDBACK, PATTERN GENERATION, LOWER BRAIN-STEM, SPEECH PRODUCTION, VOICE FUNDAMENTAL-FREQUENCY, TRANSCRANIAL MAGNETIC STIMULATION, SENSORIMOTOR INTEGRATION, EXPERIENCE-DEPENDENT MODULATION, EFFECTIVE CONNECTIVITY",
author = "Sebastian Finkel and Ralf Veit and Martin Lotze and Anders Friberg and Peter Vuust and Surjo Soekadar and Niels Birbaumer and Boris Kleber",
year = "2019",
month = may,
doi = "10.1002/hbm.24515",
language = "English",
volume = "40",
pages = "2174--2187",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "JohnWiley & Sons, Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers

AU - Finkel, Sebastian

AU - Veit, Ralf

AU - Lotze, Martin

AU - Friberg, Anders

AU - Vuust, Peter

AU - Soekadar, Surjo

AU - Birbaumer, Niels

AU - Kleber, Boris

PY - 2019/5

Y1 - 2019/5

N2 - While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in participants without singing experience. A pitch-matching singing task was performed before and after iTBS to assess corresponding effects on vocal pitch regulation. When participants could monitor auditory feedback from their own voice during singing (Experiment I), no difference in pitch-matching performance was found between iTBS sessions. However, when auditory feedback was masked with noise (Experiment II), only larynx-S1 iTBS enhanced pitch accuracy (50–250 ms after sound onset) and pitch stability (>250 ms after sound onset until the end). Results indicate that somatosensory feedback plays a dominant role in vocal pitch regulation when acoustic feedback is masked. The acoustic changes moreover suggest that right larynx-S1 stimulation affected the preparation and involuntary regulation of vocal pitch accuracy, and that kinesthetic-proprioceptive processes play a role in the voluntary control of pitch stability in nonsingers. Together, these data provide evidence for a causal involvement of right larynx-S1 in vocal pitch regulation during singing.

AB - While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in participants without singing experience. A pitch-matching singing task was performed before and after iTBS to assess corresponding effects on vocal pitch regulation. When participants could monitor auditory feedback from their own voice during singing (Experiment I), no difference in pitch-matching performance was found between iTBS sessions. However, when auditory feedback was masked with noise (Experiment II), only larynx-S1 iTBS enhanced pitch accuracy (50–250 ms after sound onset) and pitch stability (>250 ms after sound onset until the end). Results indicate that somatosensory feedback plays a dominant role in vocal pitch regulation when acoustic feedback is masked. The acoustic changes moreover suggest that right larynx-S1 stimulation affected the preparation and involuntary regulation of vocal pitch accuracy, and that kinesthetic-proprioceptive processes play a role in the voluntary control of pitch stability in nonsingers. Together, these data provide evidence for a causal involvement of right larynx-S1 in vocal pitch regulation during singing.

KW - predictive coding

KW - sensorimotor

KW - singing

KW - TMS

KW - vocal production

KW - MATCHING ACCURACY

KW - AUDITORY-FEEDBACK

KW - PATTERN GENERATION

KW - LOWER BRAIN-STEM

KW - SPEECH PRODUCTION

KW - VOICE FUNDAMENTAL-FREQUENCY

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - SENSORIMOTOR INTEGRATION

KW - EXPERIENCE-DEPENDENT MODULATION

KW - EFFECTIVE CONNECTIVITY

UR - http://www.scopus.com/inward/record.url?scp=85060332109&partnerID=8YFLogxK

U2 - 10.1002/hbm.24515

DO - 10.1002/hbm.24515

M3 - Journal article

C2 - 30666737

AN - SCOPUS:85060332109

VL - 40

SP - 2174

EP - 2187

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 7

ER -