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Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin

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We previously demonstrated that mRNA for the pro-inflammatory cytokine interleukin 20 (IL-20) is expressed in suprapapillary keratinocytes of lesional psoriatic skin. Here, we describe the distribution of IL-20 protein and the identity of the IL-20-positive cells in lesional psoriatic skin. We found that the main part of IL-20 immunoreactivity is present in mononuclear cells of the dermal papillae, and that the IL-20 positive cells located n the papillae were Langerin+, CD1a+, CD4+, and CD303+. These cells might be immature DC. In situ hybridization for IL-20 mRNA on non-lesional psoriatic skin, ex vivo stimulated with IL-1β revealed a co-localization between IL-20 mRNA and the keratinocyte marker CK14. No IL-20 mRNA was detected in the dermal mononuclear cells. Our results suggest that IL-20 is produced by keratinocytes, released into the epidermis, and then possibly taken up by papillary mononuclear cells. Our study supports that IL-20 is involved in the pathogenesis of psoriasis. This article is protected by copyright. All rights reserved.
Original languageEnglish
JournalExperimental Dermatology Online
ISSN1600-0625
DOIs
Publication statusPublished - 13 Mar 2014

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