Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi. / Harris, C.C.; Autrup, Herman; Connor, R.; Barrett, L.A.; McDowell, E.M.; Trump, B.F.

In: Science, Vol. 194, No. 4269, 03.12.1976, p. 1067-1069.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Harris, CC, Autrup, H, Connor, R, Barrett, LA, McDowell, EM & Trump, BF 1976, 'Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi', Science, vol. 194, no. 4269, pp. 1067-1069.

APA

Harris, C. C., Autrup, H., Connor, R., Barrett, L. A., McDowell, E. M., & Trump, B. F. (1976). Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi. Science, 194(4269), 1067-1069.

CBE

Harris CC, Autrup H, Connor R, Barrett LA, McDowell EM, Trump BF. 1976. Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi. Science. 194(4269):1067-1069.

MLA

Vancouver

Harris CC, Autrup H, Connor R, Barrett LA, McDowell EM, Trump BF. Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi. Science. 1976 Dec 3;194(4269):1067-1069.

Author

Harris, C.C. ; Autrup, Herman ; Connor, R. ; Barrett, L.A. ; McDowell, E.M. ; Trump, B.F. / Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi. In: Science. 1976 ; Vol. 194, No. 4269. pp. 1067-1069.

Bibtex

@article{3756352001d511dbbee902004c4f4f50,
title = "Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi",
abstract = "The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.",
author = "C.C. Harris and Herman Autrup and R. Connor and L.A. Barrett and E.M. McDowell and B.F. Trump",
year = "1976",
month = dec,
day = "3",
language = "English",
volume = "194",
pages = "1067--1069",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "4269",

}

RIS

TY - JOUR

T1 - Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi

AU - Harris, C.C.

AU - Autrup, Herman

AU - Connor, R.

AU - Barrett, L.A.

AU - McDowell, E.M.

AU - Trump, B.F.

PY - 1976/12/3

Y1 - 1976/12/3

N2 - The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.

AB - The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.

M3 - Journal article

VL - 194

SP - 1067

EP - 1069

JO - Science

JF - Science

SN - 0036-8075

IS - 4269

ER -