Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human Bronchi

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  • C.C. Harris, Denmark
  • Herman Autrup
  • R. Connor, Denmark
  • L.A. Barrett, Denmark
  • E.M. McDowell, Denmark
  • B.F. Trump, Denmark
  • Institute of Environmental and Occupational Medicine
The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.
Original languageEnglish
JournalScience
Volume194
Issue4269
Pages (from-to)1067-1069
Number of pages3
ISSN0036-8075
Publication statusPublished - 3 Dec 1976

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