Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity

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Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity. / Quarto, T; Fasano, M C; Taurisano, P; Fazio, L; Antonucci, L A; Gelao, B; Romano, R; Mancini, M; Porcelli, A; Masellis, R; Pallesen, K J; Bertolino, A; Blasi, G; Brattico, E.

In: Neuroscience, Vol. 341, 26.01.2017, p. 9-17.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Quarto, T, Fasano, MC, Taurisano, P, Fazio, L, Antonucci, LA, Gelao, B, Romano, R, Mancini, M, Porcelli, A, Masellis, R, Pallesen, KJ, Bertolino, A, Blasi, G & Brattico, E 2017, 'Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity', Neuroscience, vol. 341, pp. 9-17. https://doi.org/10.1016/j.neuroscience.2016.11.010

APA

CBE

Quarto T, Fasano MC, Taurisano P, Fazio L, Antonucci LA, Gelao B, Romano R, Mancini M, Porcelli A, Masellis R, Pallesen KJ, Bertolino A, Blasi G, Brattico E. 2017. Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity. Neuroscience. 341:9-17. https://doi.org/10.1016/j.neuroscience.2016.11.010

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Author

Quarto, T ; Fasano, M C ; Taurisano, P ; Fazio, L ; Antonucci, L A ; Gelao, B ; Romano, R ; Mancini, M ; Porcelli, A ; Masellis, R ; Pallesen, K J ; Bertolino, A ; Blasi, G ; Brattico, E. / Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity. In: Neuroscience. 2017 ; Vol. 341. pp. 9-17.

Bibtex

@article{c1ca9bdcd560450f910254dbaa7b7d17,
title = "Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity",
abstract = "Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise. Individual variation in mood induction was assessed before and after the task. Results showed mood improvement after music exposure in DRD2GG subjects and mood deterioration after noise exposure in GT subjects. Moreover, the music, as opposed to noise environment, decreased the striatal activity of GT subjects as well as the prefrontal activity of GG subjects while processing emotional faces. These findings suggest that genetic variability of dopamine receptors affects sound environment modulations of mood and emotion processing.",
author = "T Quarto and Fasano, {M C} and P Taurisano and L Fazio and Antonucci, {L A} and B Gelao and R Romano and M Mancini and A Porcelli and R Masellis and Pallesen, {K J} and A Bertolino and G Blasi and E Brattico",
note = "Copyright {\circledC} 2016 IBRO. Published by Elsevier Ltd. All rights reserved.",
year = "2017",
month = "1",
day = "26",
doi = "10.1016/j.neuroscience.2016.11.010",
language = "English",
volume = "341",
pages = "9--17",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity

AU - Quarto, T

AU - Fasano, M C

AU - Taurisano, P

AU - Fazio, L

AU - Antonucci, L A

AU - Gelao, B

AU - Romano, R

AU - Mancini, M

AU - Porcelli, A

AU - Masellis, R

AU - Pallesen, K J

AU - Bertolino, A

AU - Blasi, G

AU - Brattico, E

N1 - Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

PY - 2017/1/26

Y1 - 2017/1/26

N2 - Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise. Individual variation in mood induction was assessed before and after the task. Results showed mood improvement after music exposure in DRD2GG subjects and mood deterioration after noise exposure in GT subjects. Moreover, the music, as opposed to noise environment, decreased the striatal activity of GT subjects as well as the prefrontal activity of GG subjects while processing emotional faces. These findings suggest that genetic variability of dopamine receptors affects sound environment modulations of mood and emotion processing.

AB - Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise. Individual variation in mood induction was assessed before and after the task. Results showed mood improvement after music exposure in DRD2GG subjects and mood deterioration after noise exposure in GT subjects. Moreover, the music, as opposed to noise environment, decreased the striatal activity of GT subjects as well as the prefrontal activity of GG subjects while processing emotional faces. These findings suggest that genetic variability of dopamine receptors affects sound environment modulations of mood and emotion processing.

U2 - 10.1016/j.neuroscience.2016.11.010

DO - 10.1016/j.neuroscience.2016.11.010

M3 - Journal article

VL - 341

SP - 9

EP - 17

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -