Inter-arm blood pressure difference in early pregnancy and risk of preeclampsia

Henriette Skov, Iben Louise Riishede Christiansen, Line Rode, Kasper Pihl, Finn Stener Jørgensen, Helle Zingenberg, Pernille Nørgaard, Nina Maria Gros Pedersen, Anne Cathrine Roslev Gjerris, Stefan Rahr Wagner, Ann Tabor, Charlotte Kvist Ekelund, Puk Sandager

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Abstract

Objective
To investigate associations of inter-arm blood pressure differences (IAD) in the first trimester of pregnancy with development of preeclampsia. Bloodpressure differences between arms have been found to be related to the risk of cardiovascular disease, and since preeclampsia and cardiovascular disease share risk factors, we hypothesized that blood pressure differences in early pregnancy would be associated with the risk of preeclampsia. Methods
The study was conducted in a cohort from a Danish multicentre study: Preeclampsia screening in Denmark (PRESIDE). At the first trimester routinevisit, blood pressure was measured at an automated blood pressure station, guiding the patient to comply with international measurement guidelines. Measurements started automatically after rest for 5 minutes, and three simultaneous measurements on both arms were performed. Data wereautomatically stored from the station into a database. Furthermore, information on maternal characteristics, medical history and pregnancy outcomewas collected. Results
Preliminary results from a study population of 7044 pregnancies, show that 247 (3.5 %) developed preeclampsia. In pregnancies with preeclampsiathe absolute diastolic IAD was higher compared to pregnancies without preeclampsia (3.2 and 2.8 mmHg, respectively, P=0.001), and an absolutediastolic IAD > 5 mmHg and 10 mmHg was found in 12.6% and 1.6% compared to 9.3% and 1.0% in pregnancies without preeclampsia. There was no difference in systolic IAD in pregnancies with preeclampsia compared to pregnancies without preeclampsia (4.8 and 4.7 mmHg, P= 0.62). Thesystolic IAD was more than 10 mmHg in 8.5% of pregnancies with preeclampsia and in 6.8% in pregnancies without preeclampsia. Conclusion
The preliminary results indicate that diastolic IAD in the first trimester is associated with risk of preeclampsia. Results from the complete study
population and further analyses will be presented at the meeting.
Translated title of the contributionInter-arm blodtryksforskel i tidlig graviditet og risiko for præeklampsi
Original languageEnglish
Publication dateJun 2022
Number of pages1
Publication statusPublished - Jun 2022
EventFMF 19th World Congress 2022 - Crete Convention Centre, Kreta, Greece
Duration: 26 Jun 202230 Jun 2022

Conference

ConferenceFMF 19th World Congress 2022
LocationCrete Convention Centre
Country/TerritoryGreece
CityKreta
Period26/06/202230/06/2022

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