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Integrator is a genome-wide attenuator of non-productive transcription
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Links
- https://www.biorxiv.org/content/10.1101/2020.07.17.208702v1.full.pdf
Submitted manuscript
DOI
- https://doi.org/10.1016/j.molcel.2020.12.014
Final published version
- Søren Lykke-Andersen
- Kristina Žumer, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Ewa Šmidová Molska ,
- Jérôme O. Rouvière
- Guifen Wu
- Carina Demel, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Björn Schwalb, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Manfred Schmid ,
- Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Göttingen ,
- Torben Heick Jensen
Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.
| Original language | English |
|---|---|
| Journal | Molecular Cell |
| Volume | 81 |
| Issue | 3 |
| Pages (from-to) | 514-529.e6 |
| Number of pages | 23 |
| ISSN | 1097-2765 |
| DOIs | |
| Publication status | Published - Feb 2021 |
Bibliographical note
Publisher Copyright:
© 2020 Elsevier Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
- cleavage and polyadenylation complex, genome-wide transcription termination, integrator complex, pervasive transcription
Research areas
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