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Integrator is a genome-wide attenuator of non-productive transcription

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Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.

Original languageEnglish
JournalMolecular Cell
Volume81
Issue3
Pages (from-to)514-529.e6
Number of pages23
ISSN1097-2765
DOIs
Publication statusPublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • cleavage and polyadenylation complex, genome-wide transcription termination, integrator complex, pervasive transcription

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