Integrator is a genome-wide attenuator of non-productive transcription

Søren Lykke-Andersen*, Kristina Žumer, Ewa Šmidová Molska, Jérôme O. Rouvière, Guifen Wu, Carina Demel, Björn Schwalb, Manfred Schmid, Patrick Cramer*, Torben Heick Jensen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

3 Citations (Scopus)


Metazoan RNA polymerase II activity is promiscuous within and outside of conventional genes. Lykke-Andersen et al. show that cleavage and polyadenylation (CPA) and integrator (INT) transcription termination complexes operate genome-wide in sequence- and context-dependent manners, respectively. The INT complex is suggested to take part in quality control of non-productive transcription.

Original languageEnglish
JournalMolecular Cell
Pages (from-to)514-529.e6
Number of pages23
Publication statusPublished - Feb 2021


  • cleavage and polyadenylation complex
  • genome-wide transcription termination
  • integrator complex
  • pervasive transcription


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