Aarhus University Seal / Aarhus Universitets segl

Insulin treatment of the insulin-dependent diabetic patient undergoing minor surgery. Continuous intravenous infusion compared with subcutaneous administration

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. The former treatment resulted in lower blood glucose levels both during the infusion period (p less than 0.05) as well as the entire observation period (operative, first and second postoperative days; p less than 0.01). More blood glucose values were within the intended range of 5 to 10 mmol/litre in the glucose-insulin-potassium as compared to the conventional group (48% versus 24%; p less than 0.01). The levels of lactate, 3-hydroxybutyrate, glycerol, alanine, glucagon, insulin and growth hormone did not differ between the two groups. The infusion regimen resulted in better glycaemic control both peri-and postoperatively than the conventional subcutaneous insulin regimen in insulin-dependent diabetic patients who have minor surgery.

Original languageEnglish
JournalAnaesthesia
Volume43
Issue7
Pages (from-to)533-7
Number of pages5
ISSN0003-2409
Publication statusPublished - Jul 1988

    Research areas

  • Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 1, Female, Glucose, Humans, Infusions, Intravenous, Injections, Subcutaneous, Insulin, Male, Middle Aged, Minor Surgical Procedures, Potassium, Prospective Studies, Random Allocation, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

See relations at Aarhus University Citationformats

ID: 117558938