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Insulin action in insulin-dependent diabetics after short-term thiazide therapy

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Insulin action in insulin-dependent diabetics after short-term thiazide therapy. / Schmitz, O; Hermansen, K; Nielsen, O H; Christensen, C K; Arnfred, J; Hansen, H E; Mogensen, C E; Orskov, H; Beck-Nielsen, H.

In: Diabetes Care, Vol. 9, No. 6, 01.11.1986, p. 631-6.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Schmitz, O, Hermansen, K, Nielsen, OH, Christensen, CK, Arnfred, J, Hansen, HE, Mogensen, CE, Orskov, H & Beck-Nielsen, H 1986, 'Insulin action in insulin-dependent diabetics after short-term thiazide therapy', Diabetes Care, vol. 9, no. 6, pp. 631-6.

APA

Schmitz, O., Hermansen, K., Nielsen, O. H., Christensen, C. K., Arnfred, J., Hansen, H. E., Mogensen, C. E., Orskov, H., & Beck-Nielsen, H. (1986). Insulin action in insulin-dependent diabetics after short-term thiazide therapy. Diabetes Care, 9(6), 631-6.

CBE

Schmitz O, Hermansen K, Nielsen OH, Christensen CK, Arnfred J, Hansen HE, Mogensen CE, Orskov H, Beck-Nielsen H. 1986. Insulin action in insulin-dependent diabetics after short-term thiazide therapy. Diabetes Care. 9(6):631-6.

MLA

Vancouver

Author

Schmitz, O ; Hermansen, K ; Nielsen, O H ; Christensen, C K ; Arnfred, J ; Hansen, H E ; Mogensen, C E ; Orskov, H ; Beck-Nielsen, H. / Insulin action in insulin-dependent diabetics after short-term thiazide therapy. In: Diabetes Care. 1986 ; Vol. 9, No. 6. pp. 631-6.

Bibtex

@article{471f7da28a4043e593ef8b9387881519,
title = "Insulin action in insulin-dependent diabetics after short-term thiazide therapy",
abstract = "The influence of short-term thiazide treatment on peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetes mellitus was determined by the euglycemic insulin clamp technique. A sequential three-step hyperinsulinemic clamp was performed in six insulin-dependent diabetics before and after 2 wk of hydroflumethiazide (HFT) administration in a daily dose of 75 mg. Insulin was infused at rates of 0.5, 2.0, and 4.0 mU X kg-1 X min-1, and each dose was given for at least 120 min. Glucose uptake during the last 30 min of each step was almost identical in the two situations (2.7 +/- 0.6 vs. 2.4 +/- 0.5 mg X kg-1 X min-1, 9.6 +/- 0.9 vs. 9.7 +/- 1.2 mg X kg-1 X min-1, and 12.0 +/- 1.3 vs. 12.6 +/- 1.5 mg X kg-1 X min-1). Serum insulin levels were also similar, and blood glucose was kept at 100 +/- 3, 99 +/- 4, and 97 +/- 3 mg/dl before thiazides and at 93 +/- 6, 93 +/- 6, and 94 +/- 6 mg/dl after thiazides. Another five insulin-dependent diabetics were infused with tritiated glucose followed by insulin infusion at two rates: 0.45 and 1.0 mU X kg-1 X min-1. Basal glucose output was comparable before and after thiazides (3.63 +/- 0.24 vs. 2.97 +/- 0.26 mg X kg-1 X min-1), as was the liver response to increasing insulin concentrations. The metabolic state as assessed by HbA1c and fasting blood glucose did not differ in the two experiments.(ABSTRACT TRUNCATED AT 250 WORDS)",
keywords = "Adult, Blood Glucose, Diabetes Mellitus, Type 1, Humans, Hydroflumethiazide, Insulin, Insulin Resistance, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't",
author = "O Schmitz and K Hermansen and Nielsen, {O H} and Christensen, {C K} and J Arnfred and Hansen, {H E} and Mogensen, {C E} and H Orskov and H Beck-Nielsen",
year = "1986",
month = nov,
day = "1",
language = "English",
volume = "9",
pages = "631--6",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "6",

}

RIS

TY - JOUR

T1 - Insulin action in insulin-dependent diabetics after short-term thiazide therapy

AU - Schmitz, O

AU - Hermansen, K

AU - Nielsen, O H

AU - Christensen, C K

AU - Arnfred, J

AU - Hansen, H E

AU - Mogensen, C E

AU - Orskov, H

AU - Beck-Nielsen, H

PY - 1986/11/1

Y1 - 1986/11/1

N2 - The influence of short-term thiazide treatment on peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetes mellitus was determined by the euglycemic insulin clamp technique. A sequential three-step hyperinsulinemic clamp was performed in six insulin-dependent diabetics before and after 2 wk of hydroflumethiazide (HFT) administration in a daily dose of 75 mg. Insulin was infused at rates of 0.5, 2.0, and 4.0 mU X kg-1 X min-1, and each dose was given for at least 120 min. Glucose uptake during the last 30 min of each step was almost identical in the two situations (2.7 +/- 0.6 vs. 2.4 +/- 0.5 mg X kg-1 X min-1, 9.6 +/- 0.9 vs. 9.7 +/- 1.2 mg X kg-1 X min-1, and 12.0 +/- 1.3 vs. 12.6 +/- 1.5 mg X kg-1 X min-1). Serum insulin levels were also similar, and blood glucose was kept at 100 +/- 3, 99 +/- 4, and 97 +/- 3 mg/dl before thiazides and at 93 +/- 6, 93 +/- 6, and 94 +/- 6 mg/dl after thiazides. Another five insulin-dependent diabetics were infused with tritiated glucose followed by insulin infusion at two rates: 0.45 and 1.0 mU X kg-1 X min-1. Basal glucose output was comparable before and after thiazides (3.63 +/- 0.24 vs. 2.97 +/- 0.26 mg X kg-1 X min-1), as was the liver response to increasing insulin concentrations. The metabolic state as assessed by HbA1c and fasting blood glucose did not differ in the two experiments.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - The influence of short-term thiazide treatment on peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetes mellitus was determined by the euglycemic insulin clamp technique. A sequential three-step hyperinsulinemic clamp was performed in six insulin-dependent diabetics before and after 2 wk of hydroflumethiazide (HFT) administration in a daily dose of 75 mg. Insulin was infused at rates of 0.5, 2.0, and 4.0 mU X kg-1 X min-1, and each dose was given for at least 120 min. Glucose uptake during the last 30 min of each step was almost identical in the two situations (2.7 +/- 0.6 vs. 2.4 +/- 0.5 mg X kg-1 X min-1, 9.6 +/- 0.9 vs. 9.7 +/- 1.2 mg X kg-1 X min-1, and 12.0 +/- 1.3 vs. 12.6 +/- 1.5 mg X kg-1 X min-1). Serum insulin levels were also similar, and blood glucose was kept at 100 +/- 3, 99 +/- 4, and 97 +/- 3 mg/dl before thiazides and at 93 +/- 6, 93 +/- 6, and 94 +/- 6 mg/dl after thiazides. Another five insulin-dependent diabetics were infused with tritiated glucose followed by insulin infusion at two rates: 0.45 and 1.0 mU X kg-1 X min-1. Basal glucose output was comparable before and after thiazides (3.63 +/- 0.24 vs. 2.97 +/- 0.26 mg X kg-1 X min-1), as was the liver response to increasing insulin concentrations. The metabolic state as assessed by HbA1c and fasting blood glucose did not differ in the two experiments.(ABSTRACT TRUNCATED AT 250 WORDS)

KW - Adult

KW - Blood Glucose

KW - Diabetes Mellitus, Type 1

KW - Humans

KW - Hydroflumethiazide

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 3542455

VL - 9

SP - 631

EP - 636

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 6

ER -