Insights into hominid evolution from the gorilla genome sequence

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Insights into hominid evolution from the gorilla genome sequence. / Scally, Aylwyn; Dutheil, Julien Y; Hillier, LaDeana W; Jordan, Gregory E; Goodhead, Ian; Herrero, Javier; Hobolth, Asger; Lappalainen, Tuuli; Mailund, Thomas; Marques-Bonet, Tomas; McCarthy, Shane; Montgomery, Stephen H; Schwalie, Petra C; Tang, Y Amy; Ward, Michelle C; Xue, Yali; Yngvadottir, Bryndis; Alkan, Can; Andersen, Lars N; Ayub, Qasim; Ball, Edward V; Beal, Kathryn; Bradley, Brenda J; Chen, Yuan; Clee, Chris M; Fitzgerald, Stephen; Graves, Tina A; Gu, Yong; Heath, Paul; Heger, Andreas; Karakoc, Emre; Kolb-Kokocinski, Anja; Laird, Gavin K; Lunter, Gerton; Meader, Stephen; Mort, Matthew; Mullikin, James C; Munch, Kasper; O'Connor, Timothy D; Phillips, Andrew D; Prado-Martinez, Javier; Rogers, Anthony S; Sajjadian, Saba; Schmidt, Dominic; Shaw, Katy; Simpson, Jared T; Stenson, Peter D; Turner, Daniel J; Vigilant, Linda; Vilella, Albert J; Whitener, Weldon; Zhu, Baoli; Cooper, David N; de Jong, Pieter; Dermitzakis, Emmanouil T; Eichler, Evan E; Flicek, Paul; Goldman, Nick; Mundy, Nicholas I; Ning, Zemin; Odom, Duncan T; Ponting, Chris P; Quail, Michael A; Ryder, Oliver A; Searle, Stephen M; Warren, Wesley C; Wilson, Richard K; Schierup, Mikkel H; Rogers, Jane; Tyler-Smith, Chris; Durbin, Richard.

In: Nature, Vol. 483, No. 7388, 2012, p. 169-75.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Scally, A, Dutheil, JY, Hillier, LW, Jordan, GE, Goodhead, I, Herrero, J, Hobolth, A, Lappalainen, T, Mailund, T, Marques-Bonet, T, McCarthy, S, Montgomery, SH, Schwalie, PC, Tang, YA, Ward, MC, Xue, Y, Yngvadottir, B, Alkan, C, Andersen, LN, Ayub, Q, Ball, EV, Beal, K, Bradley, BJ, Chen, Y, Clee, CM, Fitzgerald, S, Graves, TA, Gu, Y, Heath, P, Heger, A, Karakoc, E, Kolb-Kokocinski, A, Laird, GK, Lunter, G, Meader, S, Mort, M, Mullikin, JC, Munch, K, O'Connor, TD, Phillips, AD, Prado-Martinez, J, Rogers, AS, Sajjadian, S, Schmidt, D, Shaw, K, Simpson, JT, Stenson, PD, Turner, DJ, Vigilant, L, Vilella, AJ, Whitener, W, Zhu, B, Cooper, DN, de Jong, P, Dermitzakis, ET, Eichler, EE, Flicek, P, Goldman, N, Mundy, NI, Ning, Z, Odom, DT, Ponting, CP, Quail, MA, Ryder, OA, Searle, SM, Warren, WC, Wilson, RK, Schierup, MH, Rogers, J, Tyler-Smith, C & Durbin, R 2012, 'Insights into hominid evolution from the gorilla genome sequence', Nature, vol. 483, no. 7388, pp. 169-75. https://doi.org/10.1038/nature10842

APA

Scally, A., Dutheil, J. Y., Hillier, L. W., Jordan, G. E., Goodhead, I., Herrero, J., Hobolth, A., Lappalainen, T., Mailund, T., Marques-Bonet, T., McCarthy, S., Montgomery, S. H., Schwalie, P. C., Tang, Y. A., Ward, M. C., Xue, Y., Yngvadottir, B., Alkan, C., Andersen, L. N., ... Durbin, R. (2012). Insights into hominid evolution from the gorilla genome sequence. Nature, 483(7388), 169-75. https://doi.org/10.1038/nature10842

CBE

Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen T, Mailund T, Marques-Bonet T, McCarthy S, Montgomery SH, Schwalie PC, Tang YA, Ward MC, Xue Y, Yngvadottir B, Alkan C, Andersen LN, Ayub Q, Ball EV, Beal K, Bradley BJ, Chen Y, Clee CM, Fitzgerald S, Graves TA, Gu Y, Heath P, Heger A, Karakoc E, Kolb-Kokocinski A, Laird GK, Lunter G, Meader S, Mort M, Mullikin JC, Munch K, O'Connor TD, Phillips AD, Prado-Martinez J, Rogers AS, Sajjadian S, Schmidt D, Shaw K, Simpson JT, Stenson PD, Turner DJ, Vigilant L, Vilella AJ, Whitener W, Zhu B, Cooper DN, de Jong P, Dermitzakis ET, Eichler EE, Flicek P, Goldman N, Mundy NI, Ning Z, Odom DT, Ponting CP, Quail MA, Ryder OA, Searle SM, Warren WC, Wilson RK, Schierup MH, Rogers J, Tyler-Smith C, Durbin R. 2012. Insights into hominid evolution from the gorilla genome sequence. Nature. 483(7388):169-75. https://doi.org/10.1038/nature10842

MLA

Vancouver

Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J et al. Insights into hominid evolution from the gorilla genome sequence. Nature. 2012;483(7388):169-75. https://doi.org/10.1038/nature10842

Author

Scally, Aylwyn ; Dutheil, Julien Y ; Hillier, LaDeana W ; Jordan, Gregory E ; Goodhead, Ian ; Herrero, Javier ; Hobolth, Asger ; Lappalainen, Tuuli ; Mailund, Thomas ; Marques-Bonet, Tomas ; McCarthy, Shane ; Montgomery, Stephen H ; Schwalie, Petra C ; Tang, Y Amy ; Ward, Michelle C ; Xue, Yali ; Yngvadottir, Bryndis ; Alkan, Can ; Andersen, Lars N ; Ayub, Qasim ; Ball, Edward V ; Beal, Kathryn ; Bradley, Brenda J ; Chen, Yuan ; Clee, Chris M ; Fitzgerald, Stephen ; Graves, Tina A ; Gu, Yong ; Heath, Paul ; Heger, Andreas ; Karakoc, Emre ; Kolb-Kokocinski, Anja ; Laird, Gavin K ; Lunter, Gerton ; Meader, Stephen ; Mort, Matthew ; Mullikin, James C ; Munch, Kasper ; O'Connor, Timothy D ; Phillips, Andrew D ; Prado-Martinez, Javier ; Rogers, Anthony S ; Sajjadian, Saba ; Schmidt, Dominic ; Shaw, Katy ; Simpson, Jared T ; Stenson, Peter D ; Turner, Daniel J ; Vigilant, Linda ; Vilella, Albert J ; Whitener, Weldon ; Zhu, Baoli ; Cooper, David N ; de Jong, Pieter ; Dermitzakis, Emmanouil T ; Eichler, Evan E ; Flicek, Paul ; Goldman, Nick ; Mundy, Nicholas I ; Ning, Zemin ; Odom, Duncan T ; Ponting, Chris P ; Quail, Michael A ; Ryder, Oliver A ; Searle, Stephen M ; Warren, Wesley C ; Wilson, Richard K ; Schierup, Mikkel H ; Rogers, Jane ; Tyler-Smith, Chris ; Durbin, Richard. / Insights into hominid evolution from the gorilla genome sequence. In: Nature. 2012 ; Vol. 483, No. 7388. pp. 169-75.

Bibtex

@article{dc73bcb77e44485cb6c7c747846e09c0,
title = "Insights into hominid evolution from the gorilla genome sequence",
abstract = "Gorillas are humans' closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence for the western lowland gorilla, and compare the whole genomes of all extant great ape genera. We propose a synthesis of genetic and fossil evidence consistent with placing the human-chimpanzee and human-chimpanzee-gorilla speciation events at approximately 6 and 10 million years ago. In 30% of the genome, gorilla is closer to human or chimpanzee than the latter are to each other; this is rarer around coding genes, indicating pervasive selection throughout great ape evolution, and has functional consequences in gene expression. A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing. We also compare the western and eastern gorilla species, estimating an average sequence divergence time 1.75 million years ago, but with evidence for more recent genetic exchange and a population bottleneck in the eastern species. The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution.",
author = "Aylwyn Scally and Dutheil, {Julien Y} and Hillier, {LaDeana W} and Jordan, {Gregory E} and Ian Goodhead and Javier Herrero and Asger Hobolth and Tuuli Lappalainen and Thomas Mailund and Tomas Marques-Bonet and Shane McCarthy and Montgomery, {Stephen H} and Schwalie, {Petra C} and Tang, {Y Amy} and Ward, {Michelle C} and Yali Xue and Bryndis Yngvadottir and Can Alkan and Andersen, {Lars N} and Qasim Ayub and Ball, {Edward V} and Kathryn Beal and Bradley, {Brenda J} and Yuan Chen and Clee, {Chris M} and Stephen Fitzgerald and Graves, {Tina A} and Yong Gu and Paul Heath and Andreas Heger and Emre Karakoc and Anja Kolb-Kokocinski and Laird, {Gavin K} and Gerton Lunter and Stephen Meader and Matthew Mort and Mullikin, {James C} and Kasper Munch and O'Connor, {Timothy D} and Phillips, {Andrew D} and Javier Prado-Martinez and Rogers, {Anthony S} and Saba Sajjadian and Dominic Schmidt and Katy Shaw and Simpson, {Jared T} and Stenson, {Peter D} and Turner, {Daniel J} and Linda Vigilant and Vilella, {Albert J} and Weldon Whitener and Baoli Zhu and Cooper, {David N} and {de Jong}, Pieter and Dermitzakis, {Emmanouil T} and Eichler, {Evan E} and Paul Flicek and Nick Goldman and Mundy, {Nicholas I} and Zemin Ning and Odom, {Duncan T} and Ponting, {Chris P} and Quail, {Michael A} and Ryder, {Oliver A} and Searle, {Stephen M} and Warren, {Wesley C} and Wilson, {Richard K} and Schierup, {Mikkel H} and Jane Rogers and Chris Tyler-Smith and Richard Durbin",
year = "2012",
doi = "10.1038/nature10842",
language = "English",
volume = "483",
pages = "169--75",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7388",

}

RIS

TY - JOUR

T1 - Insights into hominid evolution from the gorilla genome sequence

AU - Scally, Aylwyn

AU - Dutheil, Julien Y

AU - Hillier, LaDeana W

AU - Jordan, Gregory E

AU - Goodhead, Ian

AU - Herrero, Javier

AU - Hobolth, Asger

AU - Lappalainen, Tuuli

AU - Mailund, Thomas

AU - Marques-Bonet, Tomas

AU - McCarthy, Shane

AU - Montgomery, Stephen H

AU - Schwalie, Petra C

AU - Tang, Y Amy

AU - Ward, Michelle C

AU - Xue, Yali

AU - Yngvadottir, Bryndis

AU - Alkan, Can

AU - Andersen, Lars N

AU - Ayub, Qasim

AU - Ball, Edward V

AU - Beal, Kathryn

AU - Bradley, Brenda J

AU - Chen, Yuan

AU - Clee, Chris M

AU - Fitzgerald, Stephen

AU - Graves, Tina A

AU - Gu, Yong

AU - Heath, Paul

AU - Heger, Andreas

AU - Karakoc, Emre

AU - Kolb-Kokocinski, Anja

AU - Laird, Gavin K

AU - Lunter, Gerton

AU - Meader, Stephen

AU - Mort, Matthew

AU - Mullikin, James C

AU - Munch, Kasper

AU - O'Connor, Timothy D

AU - Phillips, Andrew D

AU - Prado-Martinez, Javier

AU - Rogers, Anthony S

AU - Sajjadian, Saba

AU - Schmidt, Dominic

AU - Shaw, Katy

AU - Simpson, Jared T

AU - Stenson, Peter D

AU - Turner, Daniel J

AU - Vigilant, Linda

AU - Vilella, Albert J

AU - Whitener, Weldon

AU - Zhu, Baoli

AU - Cooper, David N

AU - de Jong, Pieter

AU - Dermitzakis, Emmanouil T

AU - Eichler, Evan E

AU - Flicek, Paul

AU - Goldman, Nick

AU - Mundy, Nicholas I

AU - Ning, Zemin

AU - Odom, Duncan T

AU - Ponting, Chris P

AU - Quail, Michael A

AU - Ryder, Oliver A

AU - Searle, Stephen M

AU - Warren, Wesley C

AU - Wilson, Richard K

AU - Schierup, Mikkel H

AU - Rogers, Jane

AU - Tyler-Smith, Chris

AU - Durbin, Richard

PY - 2012

Y1 - 2012

N2 - Gorillas are humans' closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence for the western lowland gorilla, and compare the whole genomes of all extant great ape genera. We propose a synthesis of genetic and fossil evidence consistent with placing the human-chimpanzee and human-chimpanzee-gorilla speciation events at approximately 6 and 10 million years ago. In 30% of the genome, gorilla is closer to human or chimpanzee than the latter are to each other; this is rarer around coding genes, indicating pervasive selection throughout great ape evolution, and has functional consequences in gene expression. A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing. We also compare the western and eastern gorilla species, estimating an average sequence divergence time 1.75 million years ago, but with evidence for more recent genetic exchange and a population bottleneck in the eastern species. The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution.

AB - Gorillas are humans' closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence for the western lowland gorilla, and compare the whole genomes of all extant great ape genera. We propose a synthesis of genetic and fossil evidence consistent with placing the human-chimpanzee and human-chimpanzee-gorilla speciation events at approximately 6 and 10 million years ago. In 30% of the genome, gorilla is closer to human or chimpanzee than the latter are to each other; this is rarer around coding genes, indicating pervasive selection throughout great ape evolution, and has functional consequences in gene expression. A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing. We also compare the western and eastern gorilla species, estimating an average sequence divergence time 1.75 million years ago, but with evidence for more recent genetic exchange and a population bottleneck in the eastern species. The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution.

U2 - 10.1038/nature10842

DO - 10.1038/nature10842

M3 - Journal article

C2 - 22398555

VL - 483

SP - 169

EP - 175

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7388

ER -