Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Marja Ter Meer, Radboud University Nijmegen Medical Centre
  • ,
  • Ross Dillion, Fort Wayne Metals Research Products Corp Research and Development
  • ,
  • Signe Maria Nielsen
  • Raoul Walther
  • Rikke L. Meyer
  • Willeke F. Daamen, Radboud University Nijmegen Medical Centre
  • ,
  • Lambertus P. Van Den Heuvel, Radboud University Nijmegen Medical Centre, Instituut voor Kern- en Stralingsfysica
  • ,
  • J. Adam Van Der Vliet, Radboud University Nijmegen Medical Centre
  • ,
  • Roger M.L.M. Lomme, Radboud University Nijmegen Medical Centre
  • ,
  • Yvonne L. Hoogeveen, Radboud University Nijmegen Medical Centre
  • ,
  • Leo J. Schultze Kool, Radboud University Nijmegen Medical Centre
  • ,
  • Jeremy E. Schaffer, Fort Wayne Metals Research Products Corp Research and Development
  • ,
  • Alexander N. Zelikin

Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.

Original languageEnglish
JournalChemical Communications
Volume55
Issue4
Pages (from-to)443-446
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 1 Jan 2019

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