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Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1039/c8cc08737g
Final published version
- Marja Ter Meer, Radboud University Nijmegen Medical Centre ,
- Ross Dillion, Fort Wayne Metals Research Products Corp Research and Development ,
- Signe Maria Nielsen
- Raoul Walther
- Rikke L. Meyer
- Willeke F. Daamen, Radboud University Nijmegen Medical Centre ,
- Lambertus P. Van Den Heuvel, Radboud University Nijmegen Medical Centre, Instituut voor Kern- en Stralingsfysica ,
- J. Adam Van Der Vliet, Radboud University Nijmegen Medical Centre ,
- Roger M.L.M. Lomme, Radboud University Nijmegen Medical Centre ,
- Yvonne L. Hoogeveen, Radboud University Nijmegen Medical Centre ,
- Leo J. Schultze Kool, Radboud University Nijmegen Medical Centre ,
- Jeremy E. Schaffer, Fort Wayne Metals Research Products Corp Research and Development ,
- Alexander N. Zelikin
Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.
| Original language | English |
|---|---|
| Journal | Chemical Communications |
| Volume | 55 |
| Issue | 4 |
| Pages (from-to) | 443-446 |
| Number of pages | 4 |
| ISSN | 1359-7345 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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ID: 141503892