Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment

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Tumor cells are recognized as being highly glycolytic. However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.
Original languageEnglish
JournalRadiotherapy & Oncology
Pages (from-to)404-11
Number of pages8
Publication statusPublished - 2011

    Research areas

  • Animals, Autoradiography, Carcinoma, Squamous Cell, Cell Hypoxia, Cell Line, Tumor, Cinnamates, Female, Fluorodeoxyglucose F18, Glucose, Glycolysis, Head and Neck Neoplasms, Immunoenzyme Techniques, Lactates, Linear Models, Luminescent Measurements, Mice, Mice, Nude, Monocarboxylic Acid Transporters, Nitroimidazoles, Oxidation-Reduction, Symporters, Tumor Microenvironment, Uterine Cervical Neoplasms

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