Influence of cardiovascular risk factors, comorbidities, medication use and procedural variables on remote ischemic conditioning efficacy in patients with ST-segment elevation myocardial infarction

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DOI

Remote ischemic conditioning (RIC) confers cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI). Despite intense research, the translation of RIC into clinical practice remains a challenge. This may, at least partly, be due to confounding factors that may modify the efficacy of RIC. The present review focuses on cardiovascular risk factors, comorbidities, medication use and procedural variables which may modify the efficacy of RIC in patients with STEMI. Findings of such efficacy modifiers are based on subgroup and post-hoc analyses and thus hold risk of type I and II errors. Although findings from studies evaluating influencing factors are often ambiguous, some but not all studies suggest that smoking, non-statin use, infarct location, area-at-risk of infarction, pre-procedural Thrombolysis in Myocardial Infarction (TIMI) flow, ischemia duration and coronary collateral blood flow to the infarct-related artery may influence on the cardioprotective efficacy of RIC. Results from the on-going CONDI2/ERIC-PPCI trial will determine any clinical implications of RIC in the treatment of patients with STEMI and predefined subgroup analyses will give further insight into influencing factors on the efficacy of RIC.

Original languageEnglish
Article number3246
JournalInternational Journal of Molecular Sciences
Volume20
Issue13
Number of pages14
ISSN1661-6596
DOIs
Publication statusPublished - 2019

    Research areas

  • Acute myocardial infarction, Ischemic preconditioning, Post-infarction heart failure, Remote ischemic conditioning, ST-segment elevation myocardial infarction

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