Department of Economics and Business Economics

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Infection and Fever in Pregnancy and Autism Spectrum Disorders : Findings from the Study to Explore Early Development. / Croen, Lisa A; Qian, Yinge; Ashwood, Paul; Zerbo, Ousseny; Schendel, Diana; Pinto-Martin, Jennifer; Daniele Fallin, M; Levy, Susan; Schieve, Laura A; Yeargin-Allsopp, Marshalyn; Sabourin, Katherine R; Ames, Jennifer L.

In: Autism Research, Vol. 12, No. 10, 10.2019, p. 1551-1561.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Croen, LA, Qian, Y, Ashwood, P, Zerbo, O, Schendel, D, Pinto-Martin, J, Daniele Fallin, M, Levy, S, Schieve, LA, Yeargin-Allsopp, M, Sabourin, KR & Ames, JL 2019, 'Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development', Autism Research, vol. 12, no. 10, pp. 1551-1561. https://doi.org/10.1002/aur.2175

APA

Croen, L. A., Qian, Y., Ashwood, P., Zerbo, O., Schendel, D., Pinto-Martin, J., Daniele Fallin, M., Levy, S., Schieve, L. A., Yeargin-Allsopp, M., Sabourin, K. R., & Ames, J. L. (2019). Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development. Autism Research, 12(10), 1551-1561. https://doi.org/10.1002/aur.2175

CBE

Croen LA, Qian Y, Ashwood P, Zerbo O, Schendel D, Pinto-Martin J, Daniele Fallin M, Levy S, Schieve LA, Yeargin-Allsopp M, Sabourin KR, Ames JL. 2019. Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development. Autism Research. 12(10):1551-1561. https://doi.org/10.1002/aur.2175

MLA

Vancouver

Author

Croen, Lisa A ; Qian, Yinge ; Ashwood, Paul ; Zerbo, Ousseny ; Schendel, Diana ; Pinto-Martin, Jennifer ; Daniele Fallin, M ; Levy, Susan ; Schieve, Laura A ; Yeargin-Allsopp, Marshalyn ; Sabourin, Katherine R ; Ames, Jennifer L. / Infection and Fever in Pregnancy and Autism Spectrum Disorders : Findings from the Study to Explore Early Development. In: Autism Research. 2019 ; Vol. 12, No. 10. pp. 1551-1561.

Bibtex

@article{0bde638881c1482f93eb9c08972f7749,
title = "Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development",
abstract = "Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561.",
keywords = "autism, developmental disorder, immune function, infection, neurodevelopment, prenatal, ACTIVATION, MATERNAL IMMUNE-SYSTEM, DIAGNOSTIC OBSERVATION SCHEDULE, RISK, CHILDREN, HOSPITALIZATION, EARLY DEVELOPMENT SEED, EPIDEMIOLOGY, EXPOSURE",
author = "Croen, {Lisa A} and Yinge Qian and Paul Ashwood and Ousseny Zerbo and Diana Schendel and Jennifer Pinto-Martin and {Daniele Fallin}, M and Susan Levy and Schieve, {Laura A} and Marshalyn Yeargin-Allsopp and Sabourin, {Katherine R} and Ames, {Jennifer L}",
note = "{\textcopyright} 2019 International Society for Autism Research, Wiley Periodicals, Inc.",
year = "2019",
month = oct,
doi = "10.1002/aur.2175",
language = "English",
volume = "12",
pages = "1551--1561",
journal = "Autism Research",
issn = "1939-3792",
publisher = "John/Wiley & Sons, Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Infection and Fever in Pregnancy and Autism Spectrum Disorders

T2 - Findings from the Study to Explore Early Development

AU - Croen, Lisa A

AU - Qian, Yinge

AU - Ashwood, Paul

AU - Zerbo, Ousseny

AU - Schendel, Diana

AU - Pinto-Martin, Jennifer

AU - Daniele Fallin, M

AU - Levy, Susan

AU - Schieve, Laura A

AU - Yeargin-Allsopp, Marshalyn

AU - Sabourin, Katherine R

AU - Ames, Jennifer L

N1 - © 2019 International Society for Autism Research, Wiley Periodicals, Inc.

PY - 2019/10

Y1 - 2019/10

N2 - Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561.

AB - Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561.

KW - autism

KW - developmental disorder

KW - immune function

KW - infection

KW - neurodevelopment

KW - prenatal

KW - ACTIVATION

KW - MATERNAL IMMUNE-SYSTEM

KW - DIAGNOSTIC OBSERVATION SCHEDULE

KW - RISK

KW - CHILDREN

KW - HOSPITALIZATION

KW - EARLY DEVELOPMENT SEED

KW - EPIDEMIOLOGY

KW - EXPOSURE

UR - http://www.scopus.com/inward/record.url?scp=85069905889&partnerID=8YFLogxK

U2 - 10.1002/aur.2175

DO - 10.1002/aur.2175

M3 - Journal article

C2 - 31317667

VL - 12

SP - 1551

EP - 1561

JO - Autism Research

JF - Autism Research

SN - 1939-3792

IS - 10

ER -