Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
Infection and Fever in Pregnancy and Autism Spectrum Disorders : Findings from the Study to Explore Early Development. / Croen, Lisa A; Qian, Yinge; Ashwood, Paul; Zerbo, Ousseny; Schendel, Diana; Pinto-Martin, Jennifer; Daniele Fallin, M; Levy, Susan; Schieve, Laura A; Yeargin-Allsopp, Marshalyn; Sabourin, Katherine R; Ames, Jennifer L.
In: Autism Research, Vol. 12, No. 10, 10.2019, p. 1551-1561.Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
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TY - JOUR
T1 - Infection and Fever in Pregnancy and Autism Spectrum Disorders
T2 - Findings from the Study to Explore Early Development
AU - Croen, Lisa A
AU - Qian, Yinge
AU - Ashwood, Paul
AU - Zerbo, Ousseny
AU - Schendel, Diana
AU - Pinto-Martin, Jennifer
AU - Daniele Fallin, M
AU - Levy, Susan
AU - Schieve, Laura A
AU - Yeargin-Allsopp, Marshalyn
AU - Sabourin, Katherine R
AU - Ames, Jennifer L
N1 - © 2019 International Society for Autism Research, Wiley Periodicals, Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561.
AB - Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have not been able to separate the effects of fever itself from the impact of a specific infectious organism on the developing brain. We utilized data from the Study to Explore Early Development (SEED), a case–control study among 2- to 5-year-old children born between 2003 and 2006 in the United States, to explore a possible association between maternal infection and fever during pregnancy and risk of ASD and other developmental disorders (DDs). Three groups of children were included: children with ASD (N = 606) and children with DDs (N = 856), ascertained from clinical and educational sources, and children from the general population (N = 796), randomly sampled from state birth records. Information about infection and fever during pregnancy was obtained from a telephone interview with the mother shortly after study enrollment and maternal prenatal and labor/delivery medical records. ASD and DD status was determined by an in-person standardized developmental assessment of the child at 3–5 years of age. After adjustment for covariates, maternal infection anytime during pregnancy was not associated with ASD or DDs. However, second trimester infection accompanied by fever elevated risk for ASD approximately twofold (aOR = 2.19, 95% confidence interval 1.14–4.23). These findings of an association between maternal infection with fever in the second trimester and increased risk of ASD in the offspring suggest that the inflammatory response to the infectious agent may be etiologically relevant. Autism Res 2019, 12: 1551–1561.
KW - autism
KW - developmental disorder
KW - immune function
KW - infection
KW - neurodevelopment
KW - prenatal
KW - ACTIVATION
KW - MATERNAL IMMUNE-SYSTEM
KW - DIAGNOSTIC OBSERVATION SCHEDULE
KW - RISK
KW - CHILDREN
KW - HOSPITALIZATION
KW - EARLY DEVELOPMENT SEED
KW - EPIDEMIOLOGY
KW - EXPOSURE
UR - http://www.scopus.com/inward/record.url?scp=85069905889&partnerID=8YFLogxK
U2 - 10.1002/aur.2175
DO - 10.1002/aur.2175
M3 - Journal article
C2 - 31317667
VL - 12
SP - 1551
EP - 1561
JO - Autism Research
JF - Autism Research
SN - 1939-3792
IS - 10
ER -